Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CCR5-UTILIZING AND CXCR4-UTILIZING STRAINS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXHIBIT DIFFERENTIAL TROPISM AND PATHOGENESIS IN-VIVO
Autore:
BERKOWITZ RD; ALEXANDER S; BARE C; LINQUISTSTEPPS V; BOGAN M; MORENO ME; GIBSON L; WIEDER ED; KOSEK J; STODDART CA; MCCUNE JM;
Indirizzi:
UNIV CALIF SAN FRANCISCO,GLADSTONE INST VIROL & IMMUNOL,POB 419100 SAN FRANCISCO CA 94141 UNIV CALIF SAN FRANCISCO,GLADSTONE INST VIROL & IMMUNOL SAN FRANCISCOCA 94141 UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 00000 STANFORD UNIV,DEPT PATHOL STANFORD CA 94305 VET HOSP PALO ALTO CA 00000
Titolo Testata:
Journal of virology (Print)
fascicolo: 12, volume: 72, anno: 1998,
pagine: 10108 - 10117
SICI:
0022-538X(1998)72:12<10108:CACSOH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCID-HU MOUSE; DISEASE PROGRESSION; VIRAL PHENOTYPE; IN-VIVO; HIV-1 INFECTION; HUMAN THYMUS; CELLS; TRANSMISSION; DEPLETION; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Berkowitz et al., "CCR5-UTILIZING AND CXCR4-UTILIZING STRAINS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXHIBIT DIFFERENTIAL TROPISM AND PATHOGENESIS IN-VIVO", Journal of virology (Print), 72(12), 1998, pp. 10108-10117

Abstract

CCR5-utilizing (R5) and CXCR4-utilizing (X4) strains of human immunodeficiency virus type 1 (HIV-1) have been studied intensively in vitro,but the pathologic correlates of such differential tropism in vivo remain incompletely defined. In this study, X4 and R5 strains of HIV-1 were compared for tropism and pathogenesis in SCID-hu Thy/Liv mice, an in vivo model of human thymopoiesis. The X4 strain NL4-3 replicates quickly and extensively in thymocytes in the cortex and medulla, causingsignificant depletion. In contrast, the R5 strain Ba-L initially infects stromal cells including macrophages in the thymic medulla, withoutany obvious pathologic consequence. After a period of 3 to 4 weeks, Ba-L infection slowly spreads through the thymocyte populations, occasionally culminating in thymocyte depletion after week 6 of infection. During the entire time of infection, Ba-L did not mutate into variants capable of utilizing CXCR4. Therefore, X4 strains are highly cytopathic after infection of the human thymus. In contrast, infection with R5 strains of HIV-1 can result in a two-phase process in vivo, involving apparently nonpathogenic replication in medullary stromal cells followed by cytopathic replication in thymocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:31:02