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Titolo:
INFLUENCE OF CARDIOPULMONARY BYPASS-SURGERY ON CANCER-SPECIFIC SURVIVAL RATE OF PATIENTS WITH COLORECTAL-CANCER
Autore:
PLATELL C;
Indirizzi:
UNIV FREMANTLE,FREMANTLE HOSP,DEPT SURG FREMANTLE WA AUSTRALIA
Titolo Testata:
Diseases of the colon & rectum
fascicolo: 11, volume: 41, anno: 1998,
pagine: 1371 - 1375
SICI:
0012-3706(1998)41:11<1371:IOCBOC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY RESPONSE; RECURRENCE; MALIGNANCY; METASTASES; PROTEINS;
Keywords:
COLORECTAL CANCER; CANCER; SURGERY; INFLAMMATION; CARDIOPULMONARY BYPASS SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
C. Platell, "INFLUENCE OF CARDIOPULMONARY BYPASS-SURGERY ON CANCER-SPECIFIC SURVIVAL RATE OF PATIENTS WITH COLORECTAL-CANCER", Diseases of the colon & rectum, 41(11), 1998, pp. 1371-1375

Abstract

PURPOSE: There is evidence of a relationship between inflammation andcancer growth and spread. Cardiopulmonary bypass surgery is known to induce a systemic inflammatory response. The aim of this study was to determine whether cardiopulmonary bypass surgery influences the cancer-specific survival rate in patients with colorectal cancer. METHODS: The Fremantle Hospital database on patients with colorectal cancer (477patients) was linked to the Western Australian Hospital Morbidity Database System. Patients who had colorectal cancer after having undergone cardiopulmonary bypass surgery (n = 7) were identified. The cancer-specific survival rate for these patients was compared with that for a group of controls derived from the hospital database. Controls were matched for age, gender, tumor location, tumor stage, operative procedure, and adjuvant therapy (n = 26). RESULTS: The cancer-specific survival rate of the seven patients with colorectal cancer who had undergone cardiopulmonary bypass surgery was significantly lower than that for control patients (5-year survival rate, 34 ys. 71 percent, respectively; P < 0.05; hazard ratio, 2.9; 95 percent confidence interval, 1.5-4.4). Of the two patients in the study group who survived for 18 months, one had liver metastases and the other had local recurrence of a rectal cancer. CONCLUSION: In patients with colorectal cancer, having undergone cardiopulmonary bypass surgery was associated with a reduced cancer-specific survival rate. Additional studies are required to validatethis association and explore the possibility of a causal relationship.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:49:46