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Titolo:
NMDA AND AMPA RECEPTORS EVOKE TRANSMITTER RELEASE FROM NORADRENERGIC AXON TERMINALS IN THE RAT SPINAL-CORD
Autore:
SUNDSTROM E; HOLMBERG L; SOUVERBIE F;
Indirizzi:
KAROLINSKA INST,KFC NOVUM,DIV GERIATR MED,DEPT CLIN NEUROSCI & FAMILYMED S-14186 HUDDINGE SWEDEN
Titolo Testata:
Neurochemical research
fascicolo: 12, volume: 23, anno: 1998,
pagine: 1501 - 1507
SICI:
0364-3190(1998)23:12<1501:NAARET>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 NOREPINEPHRINE RELEASE; HORN NOCICEPTIVE NEURONS; DORSAL HORN; NORADRENALINE RELEASE; GLUTAMATE RECEPTORS; HIPPOCAMPAL SLICES; CONCANAVALIN-A; AMINO-ACIDS; DESENSITIZATION; CYCLOTHIAZIDE;
Keywords:
NMDA; AMPA; KAINIC ACID; [H-3]NORADRENALINE; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
E. Sundstrom et al., "NMDA AND AMPA RECEPTORS EVOKE TRANSMITTER RELEASE FROM NORADRENERGIC AXON TERMINALS IN THE RAT SPINAL-CORD", Neurochemical research, 23(12), 1998, pp. 1501-1507

Abstract

N-methyl-D-aspartate (NMDA) stimulated release of [H-3]noradrenaline (NA) from prelabelled rat spinal cord slices. The release Mras partially insensitive to tetrodotoxin (TTX) and was inhibited by the NMDA antagonist MK-801. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) also evoked release of [H-3]NA, which was enhanced by blocking AMPA receptor desensitization with cyclothiazide. AMPA-evoked release was inhibited by the non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(NBQX) but was not affected by TTX. NMDA and AMPA showed synergistic effects, indicating co-existence of NMDA and AMPA receptors on noradrenergic terminals. Kainate evoked [H-3]NA release only at highconcentrations and the release was not potentiated by blocking kainate receptor desensitization with concanavalin A. Thus, the results indicate that there are stimulatory presynaptic NMDA and AMPA receptors onnoradrenergic axon terminals in the spinal cord and that they interact synergistically to evoke release of [H-3]NA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:51:41