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Titolo:
RECOMMENDATIONS FOR MEDICAL-MANAGEMENT OF HEREDITARY BREAST AND OVARIAN-CANCER - THE FRENCH NATIONAL AD HOC COMMITTEE
Autore:
EISINGER F; ALBY N; BREMOND A; DAUPLAT J; ESPIE M; JANIAUD P; KUTTENN F; LEBRUN JP; LEFRANC JP; PIERRET J; SOBOL H; STOPPALYONNET D; THOUVENIN D; TRISTANT H; FEINGOLD J;
Indirizzi:
INST J PAOLI I CALMETTES,INSERM,CRI 9703,DEPT PREVENT,232 BD ST MARGUERITE F-13009 MARSEILLE FRANCE FRENCH NATL LEAGUE CANC PARIS FRANCE CTR LEON BERARD F-69373 LYON FRANCE JEAN PERRIN CTR CLERMONT FERRA FRANCE ST LOUIS HOSP PARIS FRANCE HOP HENRI MONDOR,INSERM,SC 15 F-94010 CRETEIL FRANCE HOP NECKER ENFANTS MALAD PARIS FRANCE GRP HOSP PITIE SALPETRIERE F-75634 PARIS FRANCE INSERM,U304 PARIS FRANCE INST CURIE PARIS FRANCE UNIV PARIS 08 PARIS FRANCE INSERM,U155 PARIS FRANCE
Titolo Testata:
Annals of oncology
fascicolo: 9, volume: 9, anno: 1998,
pagine: 939 - 950
SICI:
0923-7534(1998)9:9<939:RFMOHB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILY HISTORY; GERMLINE MUTATIONS; SELF-EXAMINATION; BRCA1 MUTATIONS; YOUNG-WOMEN; FOLLOW-UP; HISTOPROGNOSTIC GRADE; SUSCEPTIBILITY GENE; LINKAGE ANALYSIS; RISK;
Keywords:
BRCA1; BRCA2; BREAST CANCER; GUIDELINES; OVARIAN CANCER; PREVENTIVE CARE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
F. Eisinger et al., "RECOMMENDATIONS FOR MEDICAL-MANAGEMENT OF HEREDITARY BREAST AND OVARIAN-CANCER - THE FRENCH NATIONAL AD HOC COMMITTEE", Annals of oncology, 9(9), 1998, pp. 939-950

Abstract

Background and purpose: Almost 10% of breast and ovarian cancers are familial, and the majority are linked to BRCA1 and BRCA2 germline mutations, Despite uncertainty about the management of female gene carriers, consensus guidelines have been established to assist practitioners and consultees in making health care decisions. Methodology: The Ad Hoc Committee was composed of 14 experts appointed by the French National Institute for Health and Medical Research, all of whom attended eleven workshops at which more than 3500 articles were systematically analyzed. Five additional experts critically analysed the first version ofthe report. Criteria and decision process: On a probability scale of the risk of developing breast or ovarian cancers, two thresholds were defined for use in determining whether an intervention would be worthwhile. The first is the threshold above which an intervention can be envisaged or recommended, and the second is the one below which an intervention can be ruled out: between the two, the decision has to be madeon a case-by-case basis. Screening and preventive strategies analyzed. With respect to breast cancer: 1) hormonal interventions; 2) primaryprevention (diet, family planning and chemoprevention); 3) screening (breast self-examination, clinician breast examination, tumor markers,imaging); 3) prophylactic mastectomy, With respect to ovarian cancer:1! hormonal stimulation; 2) screening (clinical screening, ultrasoundand tumor markers); 3) prophylactic oophorectomy. Main conclusions. For each strategy the following points were addressed: the information to be given to the consultee, the procedure and the indications. In addition, the committee's opinion about BRCA1 and BRCA2 mutation screening is that population-based, or even large-scale, implementation are not justified. Although no scientific evidence is available, the committee feels that specific management is indispensable and advocates the use of defined and evaluated procedures, and participation in clinicaltrials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:50:44