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Titolo:
NEUROFIBROMATOSIS - A COMMON NEUROCUTANEOUS DISORDER
Autore:
KARNES PS;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT MED GENET,200 1ST ST SW ROCHESTER MN 55905
Titolo Testata:
Mayo Clinic proceedings
fascicolo: 11, volume: 73, anno: 1998,
pagine: 1071 - 1076
SICI:
0025-6196(1998)73:11<1071:N-ACND>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILATERAL ACOUSTIC NEUROFIBROMATOSIS; MALIGNANT MYELOID DISORDERS; CENTRAL-NERVOUS-SYSTEM; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; TYPE-1 GENE; NOONAN SYNDROME; SHEATH TUMORS; BONE-MARROW; NF1 GENE; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Karnes, "NEUROFIBROMATOSIS - A COMMON NEUROCUTANEOUS DISORDER", Mayo Clinic proceedings, 73(11), 1998, pp. 1071-1076

Abstract

Neurofibromatosis (NF) type 1 (NF-1) is one of the most common of theneurocutaneous conditions, whereas NF type 2 (NF-2) accounts for an extremely small percentage of the total cases of NF, Indeed, most physicians will probably encounter at least one or two patients with NF-1 during the course of their practice. The manifestations can be varied and subtle; thus, the condition can sometimes be difficult to recognize, Nonetheless, the diagnosis of NF-1 is often clinically possible by the time the person is 10 years old, In this article, the diagnostic criteria for the most common types of NF are discussed, the common and some of the serious manifestations of both NF-1 and NF-2 are described,and suggestions for follow-up care are offered. Of importance, physicians must recognize that, although NF-1 and NF-2 share a common name, they are due to mutations in two different genes. Cure is not yet possible; thus, treatment is primarily symptomatic. A multidisciplinary treatment team is often helpful, particularly for patients with complicated problems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:41:48