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Titolo:
RECURRENCE OF MICROCHOLELITHIASIS - PREVENTION THERAPY WITH URSODEOXYCHOLIC ACID
Autore:
GUMA C; VIOLA L; THOME M; GALDAME O; FACELLI A; DIBUCCI A; VAIMBERG D;
Indirizzi:
PARANA 1132 RA-1018 BUENOS AIRES DF ARGENTINA HOSP INTERZONAL GEN AGUDOS EVA PERON,SECC HEPATOL,CTR MED SMATA BUENOS AIRES DF ARGENTINA HOSP INTERZONAL GEN AGUDOS EVA PERON,DIV GASTROENTEROL BUENOS AIRES DF ARGENTINA
Titolo Testata:
Medicina
fascicolo: 5, volume: 58, anno: 1998,
pagine: 474 - 476
SICI:
0025-7680(1998)58:5<474:ROM-PT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
SPA
Soggetto:
BILIARY SLUDGE; GALLSTONE RECURRENCE; ACUTE-PANCREATITIS; ORIGIN;
Keywords:
MICROCHOLE LITHIASIS; RECURRENT GALLSTONES; URSODEOXYCHOLIC ACID THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
C. Guma et al., "RECURRENCE OF MICROCHOLELITHIASIS - PREVENTION THERAPY WITH URSODEOXYCHOLIC ACID", Medicina, 58(5), 1998, pp. 474-476

Abstract

Recurrent gallstones are the limiting factor for every non surgical treatment. In order to determine the optimal prevention therapy, 30 patients after successful dissolution therapy of microcholelithiasis (MCL) with ursodeoxycholic acid (UDCA), were randomized by the double blind method to receive UDCA therapy. This was administered either as 150 mg (N = 15, group I) or 300 mg per day (N = 15, group Il). There was afollow-up period of 12 months with clinical examination every month and upper abdominal sonography on days 180 and 360. Recurrent gallstones, after a 12-month period, was 6.7% (1/15) in group II versus 66% (10/15) in group I (P < 0.005). When recurrence was examined according tothe number of gallstones, it reached 8% (1/12) in the solitary MCL vs55.5% (10/18) in multiple MCL (P < 0.005). The recurrence was always symptomatic (biliary pain) and developed in 11 out of 30 pts, as MCL in 7 and as biliary sludge in the remainder 4. We conclude that a dailydose of 300 mg of UDCA was effective in reducing the recurrent gallstones in more than 90% of cases treated for 12 months. The significant risk factors associated with recurrence were the UDCA low dose and multiple stones. Biliary sludge represented 36% of the recurrence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:06:14