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Titolo:
PROSPECTIVE MAGNETIC-RESONANCE-IMAGING IDENTIFICATION OF FOCAL CORTICAL DYSPLASIA, INCLUDING THE NON-BALLOON CELL SUBTYPE
Autore:
CHAN S; CHIN SS; NORDLI DR; GOODMAN RR; DELAPAZ RL; PEDLEY TA;
Indirizzi:
COLUMBIA PRESBYTERIAN MED CTR,DEPT RADIOL,MILSTEIN HOSP BLDG,3RD FLOOR,177 FT WASHINGTON AV NEW YORK NY 10032 COLUMBIA PRESBYTERIAN MED CTR,DEPT PATHOL NEW YORK NY 10032 COLUMBIA PRESBYTERIAN MED CTR,DEPT NEUROL NEW YORK NY 10032 COLUMBIA PRESBYTERIAN MED CTR,DEPT PEDIAT NEW YORK NY 10032 COLUMBIA PRESBYTERIAN MED CTR,DEPT NEUROSURG NEW YORK NY 10032
Titolo Testata:
Annals of neurology
fascicolo: 5, volume: 44, anno: 1998,
pagine: 749 - 757
SICI:
0364-5134(1998)44:5<749:PMIOFC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANTILE SPASMS; TUBEROUS SCLEROSIS; MR; EPILEPSY; ABNORMALITIES; SYSTEM; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S. Chan et al., "PROSPECTIVE MAGNETIC-RESONANCE-IMAGING IDENTIFICATION OF FOCAL CORTICAL DYSPLASIA, INCLUDING THE NON-BALLOON CELL SUBTYPE", Annals of neurology, 44(5), 1998, pp. 749-757

Abstract

The purpose of this study was to determine the role of high-resolution T2-weighted fast multiplanar inversion-recovery (FMPIR) magnetic resonance (MR) imaging in detecting and delineating microscopic focal cortical dysplasia (FCD). We performed MR scans with FMPIR on 42 patientswith suspected neocortical epilepsy. Ten MR studies mere read prospectively as showing FCD; these case histories, electroencephalographic studies, and neuroimaging data were reviewed. Eight of these patients subsequently underwent focal cortical resection guided by intraoperative electrocorticography. The MR findings were correlated with pathological findings in these 8 patients. For purposes of radiological-pathological correlation, the FCD lesions were divided into two classes. Radiological classification was based on the absence (type A) or presence (type B) of T2 prolongation of the subcortical white matter. Pathological grading as type I or type II was based on a previously described pathological grading system. Specific MR findings associated with FCD included focal blurring of the gray-white matter interface (n = 9), thickening of the cortical ribbon (n = 7), and T2 prolongation of the subcortical white matter (n = 4). In 3 patients, the only MR finding thatsuggested FCD was localized blurring of the gray-white matter junction. In 2 of these 3 patients, the MR diagnosis of FCD could be made only by FMPIR. FCD was confirmed histologically in 7 of 8 patients, with insufficient tissue for complete histopathological evaluation in 1 case. Radiological classification of FCD agreed with pathological classification in 5 of 7 cases. Correlation of MR findings with intraoperative electrocorticography results indicated that the MR study localized the epileptogenic lesion correctly in 8 of 8 cases. Scalp ictal electroencephalographic studies localized the epileptogenic lesion in 5 of 8 cases; positron emission tomographic scans were focally abnormal in 3 of 3 cases. FMPIR MR imaging permitted accurate diagnosis and localization of FCD in all patients with pathologically proved FCD. MR identification of FCD aided presurgical planning and intraoperative management of these patients.

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Documento generato il 08/07/20 alle ore 00:57:30