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Titolo:
REGULATION OF INTRINSIC AND SYNAPTIC PROPERTIES OF NEONATAL RAT TRIGEMINAL MOTONEURONS BY METABOTROPIC GLUTAMATE RECEPTORS
Autore:
DELNEGRO CA; CHANDLER SH;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI,2851 SLICHTER HALL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI LOS ANGELES CA 90095
Titolo Testata:
The Journal of neuroscience
fascicolo: 22, volume: 18, anno: 1998,
pagine: 9216 - 9226
SICI:
0270-6474(1998)18:22<9216:ROIASP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITS CALCIUM CURRENTS; RHYTHMICAL JAW MOVEMENTS; PATCH-CLAMP RECORDINGS; GUINEA-PIG; IN-VITRO; HIPPOCAMPAL-NEURONS; ELEVATOR MOTONEURONS; ELECTRICAL GEOMETRY; MEMBRANE-PROPERTIES; TRACTUS-SOLITARIUS;
Keywords:
(1S,3R)-ACPD; MCPG; LEAKAGE K+ CURRENTS; CA2+ CURRENTS; MEPSCS; MGLUR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Delnegro e S.H. Chandler, "REGULATION OF INTRINSIC AND SYNAPTIC PROPERTIES OF NEONATAL RAT TRIGEMINAL MOTONEURONS BY METABOTROPIC GLUTAMATE RECEPTORS", The Journal of neuroscience, 18(22), 1998, pp. 9216-9226

Abstract

We studied how metabotropic glutamate receptor (mGluR) activation modifies the synaptic and intrinsic membrane properties of neonatal rat trigeminal motoneurons using the broad-spectrum mGluR agonist (1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid [(1S,3R)-ACPD], group I/II antagonist (+/-)-alpha-methyl-4-carboxy-phenylglycine (MCPG), and group III agonist L-2-amino-4-phosphonobutanoate (L-APL). (1S,3R)-ACPD depressed excitatory transmission to trigeminal motoneurons presynapticallyand postsynaptically via presynaptic inhibition and by reducing the currents carried by ionotropic glutamate receptors selective for AMPA. (1S,3R)-ACPD also depolarized trigeminal motoneurons and increased input resistance by suppressing a Ba2+-sensitive leakage K+ current. These effects were not mimicked by L-AP4 (100-200 mu M). High-threshold Ca2+ currents were also suppressed by (1S,3R)-ACPD. Repetitive stimulation of excitatory premotoneurons mimicked the postsynaptic effects of (1S,3R)-ACPD. The postsynaptic effects of (IS,3R)-ACPD and repetitive stimulation were both antagonized by MCPG, suggesting that mGluRs were similarly activated in both experiments. We conclude that mGluRs can be recruited endogenously by glutamatergic premotoneurons and that mGluR-mediated depression of excitatory transmission, combined with increased postsynaptic excitability, enhances the signal-to-noise ratio of oral-related synaptic input to trigeminal motoneurons during rhythmicaljaw movements.

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Documento generato il 25/11/20 alle ore 18:35:50