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Titolo:
CONTRACTILE PROPERTIES OF URETERS FROM RATS WITH INFRAVESICAL URINARYOUTLET OBSTRUCTION
Autore:
HJORTSWANG H; MALMQVIST U; UVELIUS B; ARNER A;
Indirizzi:
LUND UNIV,DEPT PHYSIOL & NEUROSCI,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & NEUROSCI S-22362 LUND SWEDEN LUND UNIV,DEPT UROL S-22362 LUND SWEDEN
Titolo Testata:
Urological research
fascicolo: 5, volume: 26, anno: 1998,
pagine: 337 - 342
SICI:
0300-5623(1998)26:5<337:CPOUFR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTFLOW OBSTRUCTION; BLADDER;
Keywords:
URETER; URINARY BLADDER; SMOOTH MUSCLE; HYPERTROPHY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
H. Hjortswang et al., "CONTRACTILE PROPERTIES OF URETERS FROM RATS WITH INFRAVESICAL URINARYOUTLET OBSTRUCTION", Urological research, 26(5), 1998, pp. 337-342

Abstract

Mechanical properties of ureters from rats with infravesical urinary outflow obstruction were studied in vitro. Urinary outflow obstructionwas created by partial ligation of the urethra in female rats. After 10 days a marked hypertrophy of the urinary bladder and a dilatation of the ureters were observed. Proximal and distal segments of the ureters from these animals were isolated and mounted in a wire myograph forforce registration. Comparisons were made with ureters from control rats. The ureters from the rats with urinary outflow obstruction exhibited a large increase in lumen diameter and an unchanged thickness of the muscle layer. These data suggest that the dilatation of the uretersis associated with growth of the smooth muscle in the wall. All ureter preparations were relaxed in normal physiological salt solution. When the extracellular K+ concentration was increased to 20 mM the dilated ureters became spontaneously active. At [K+] in the range 20-40 mM in the presence of noradrenaline (10(-5) M) all ureters exhibited high-frequency spontaneous contractions. The dilated ureters had a lower frequency of spontaneous contractions and a higher force. The results show a pronounced remodelling of the ureter wall following infravesical outlet obstruction. The structural changes were associated with alterations in the contraction pattern of the preparations, most probably reflecting changes in the excitation-contraction coupling of the growingcells.

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Documento generato il 26/09/20 alle ore 14:24:00