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Titolo:
CYSTOMETRICAL EVALUATION OF ACUTE AND CHRONIC OVERDISTENSION IN THE RAT URINARY-BLADDER
Autore:
BERGGREN T; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN
Titolo Testata:
Urological research
fascicolo: 5, volume: 26, anno: 1998,
pagine: 325 - 330
SICI:
0300-5623(1998)26:5<325:CEOAAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; OUTLET OBSTRUCTION; ACUTE DISTENSION; DNA-SYNTHESIS; INSTABILITY; MICTURITION; CONTRACTILE; INNERVATION; HYPERTROPHY; MUSCLE;
Keywords:
URINARY BLADDER; OBSTRUCTION; HYPERTROPHY; CYSTOMETRY; ATROPINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
T. Berggren e B. Uvelius, "CYSTOMETRICAL EVALUATION OF ACUTE AND CHRONIC OVERDISTENSION IN THE RAT URINARY-BLADDER", Urological research, 26(5), 1998, pp. 325-330

Abstract

The urodynamic effects of an experimental, partial infravesical outlet obstruction in rats were studied and compared with the effects in sham-operated controls, and in animals that had undergone 24 h of total outlet obstruction. The animals were studied up to 42 days after surgery. Bladder weight increased with time in the partially obstructed group to reach a final value of 6 times that of the control. In water loading experiments micturition volume was unaffected by sham operation. In the partially obstructed bladders it decreased initially but normalized with time. In the group that had undergone 24 h of total obstruction micturition volume also decreased initially but then became significantly higher than in the controls. In cystometry experiments the partially obstructed bladders developed a considerable residual urine andincreased threshold and micturition pressures. Detrusor instability was present already after 10 days. Also in the cystometry experiments the bladders that had been totally obstructed;for 24 h had increased micturition volumes. Residual volume was only slightly affected by atropine in the control and partially obstructed bladders but increased 7-fold in rats in which the bladder had been totally obstructed for 24 h 42 days previously. We conclude that there is a close relationship between bladder weight, residual volume and micturition pressure in the partially obstructed bladder, and that 24 h of total obstruction results in disturbances of bladder function that might be related to denervation phenomena previously reported by others.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:07:34