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Titolo:
THE DISTRIBUTION OF INTRAMURAL NERVES IN URINARY-BLADDER AFTER PARTIAL DENERVATION IN THE FEMALE RAT
Autore:
UVELIUS B; GABELLA G;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN UNIV COLL LONDON,DEPT ANAT & DEV BIOL LONDON WC1E 6BT ENGLAND
Titolo Testata:
Urological research
fascicolo: 5, volume: 26, anno: 1998,
pagine: 291 - 297
SICI:
0300-5623(1998)26:5<291:TDOINI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PELVIC GANGLION; OBSTRUCTION; NEURONS;
Keywords:
URINARY BLADDER; RAT; PELVIC GANGLION; INNERVATION; DENERVATION; PLASTICITY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
B. Uvelius e G. Gabella, "THE DISTRIBUTION OF INTRAMURAL NERVES IN URINARY-BLADDER AFTER PARTIAL DENERVATION IN THE FEMALE RAT", Urological research, 26(5), 1998, pp. 291-297

Abstract

We evaluated the degree of neuronal plasticity following a partial denervation of the rat urinary bladder. Using acetylcholinesterase staining we found that the postganglionic nerves from the pelvic ganglion reach the intact bladder as 1-4 nerve trunks on each side, slightly ventral and caudal to the ureteral orifices. Normally a few thinner nerves also reach the bladder posterolateral to the ureterovesical junction. The nerves ventral to the ureters run in the ventral longitudinal muscle layer as well-defined trunks with a pattern that does not differ much from one animal to another. The nerves reaching the bladder dorsolaterally innervate the dorsolateral aspects in a more irregular fashion. Some anastomoses are found across the midline between nerves from either side. This nerve pattern is already in place in newborn rats. After removal of the pelvic ganglion on one side in the adult rat the ipsilateral ventral nerves rapidly degenerate, whereas some dorsolateral nerves usually survive. Axons from the intact ventral nerves can be seen crossing over to the denervated side in the anastomoses. After 13weeks the surviving Ventral nerves, which normally run at some distance from the Ventral midline, now pun in the midline with equal amountsof ventral longitudinal muscle on either side, and with their branches evenly distributed to both sides. The same pattern is seen after 27 weeks. Unilateral ganglionectomy in 3-week-old rats leads to the same changes in nerve distribution as in the adult rat. We conclude that there is a high degree of plasticity in the bladder innervation following a partial denervation, and that this plasticity includes the distribution of its main intramural nerve trunks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:34:30