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Titolo:
PROLACTIN RECEPTOR ANTAGONISTS
Autore:
KUO CB; COSS D; WALKER AM;
Indirizzi:
UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521 UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521
Titolo Testata:
ENDOCRINE
fascicolo: 2, volume: 9, anno: 1998,
pagine: 121 - 131
SICI:
1355-008X(1998)9:2<121:PRA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; RAT LYMPHOMA-CELLS; EXTRACELLULAR DOMAIN; LACTOGENIC HORMONES; SIGNAL-TRANSDUCTION; OVINE PROLACTIN; RADIOIMMUNOASSAY ACTIVITIES; ERYTHROPOIETIN RECEPTOR; DIFFERENT BIOASSAY; CRYSTAL-STRUCTURE;
Keywords:
PROLACTIN ANTAGONIST; PROLACTIN RECEPTOR; PROLACTIN-RECEPTOR INTERACTION; SIGNALING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
C.B. Kuo et al., "PROLACTIN RECEPTOR ANTAGONISTS", ENDOCRINE, 9(2), 1998, pp. 121-131

Abstract

Most prolactin (PRL) in the circulation is produced by the pituitary. However, a wide variety of traditional target tissues Of the hormone have also been shown to produce their own prolactin. The amount produced per cell is low, but may well be sufficient for autocrine/paracrineactivity. Although dopamine agonists allow one to study the target tissue effects of pituitary PRL, other agents, such as PRL receptor (PRLR) antagonist, are needed to analyze autocrine/paracrine loops. With PRLR antagonists, it should be possible to dissect out the role of extrapituitary prolactin in both the normal physiology, and the pathophysiology of various tissues. In tissues where the locally produced PRL may promote disease, such antagonists have the potential to be importanttherapeutics. This article briefly, but critically, reviews current understanding of PRL-receptor interactions and initial signaling, and describes the development of both growth hormone (GH) and PRL antagonists within that context. In the final section, results with a very potent PRL antagonist further one theme of the article, which is whether the simple receptor dimerization model explains al signal transduction following PRLR binding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:00:15