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Titolo:
EXERCISE CAPACITY AND HORMONAL RESPONSE IN ADULTS WITH CHILDHOOD-ONSET GROWTH-HORMONE DEFICIENCY DURING LONG-TERM SOMATROPIN TREATMENT
Autore:
GULLESTAD L; BIRKELAND K; BJONERHEIM R; DJOSELAND O; TRYGSTAD O; SIMONSEN S;
Indirizzi:
UNIV OSLO,RIKSHOSP,DEPT MED B N-0027 OSLO 1 NORWAY UNIV OSLO,RIKSHOSP,DEPT PEDIAT N-0027 OSLO 1 NORWAY AKER HOSP,HORMONE LAB OSLO NORWAY
Titolo Testata:
Growth hormone & IGF research
fascicolo: 5, volume: 8, anno: 1998,
pagine: 377 - 384
SICI:
1096-6374(1998)8:5<377:ECAHRI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-COMPOSITION; REPLACEMENT THERAPY; METABOLISM; PERFORMANCE; PROTOCOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
L. Gullestad et al., "EXERCISE CAPACITY AND HORMONAL RESPONSE IN ADULTS WITH CHILDHOOD-ONSET GROWTH-HORMONE DEFICIENCY DURING LONG-TERM SOMATROPIN TREATMENT", Growth hormone & IGF research, 8(5), 1998, pp. 377-384

Abstract

Growth hormone (GH) deficiency in adults in associated with reduced muscular strength and peak oxygen uptake (peak Vo(2)). How these variables are influenced by long-term somatropin therapy in adults with childhood onset GH-deficiency has not been precisely defined. The effect of somatropin treatment in 20 childhood onset GH-deficient adults on muscular strength, maximal exercise capacity, and hormonal response to exercise were therefore examined in a double-blind placebo-controlled study with recombinant human GH (rhGH, 12 mu g/kg/day) for 6 months, followed by 36 months of open-labeled uninterrupted therapy, after whichtreatment was stopped for 9 months. After 6 months of treatment, exercise capacity increased significantly, as assessed by time to exhaustion [mean change (95% CI) 0.8 (0.2, 1.4) min, P < 0.05], total (accumulated) work [11.6 (0.8, 22.4) kJ, P < 0.05] and peak Vo(2) [2.6 (0.3, 4.9) ml/kg/min, P < 0.01], whereas no significant changes were observedduring placebo. This effect on exercise capacity remained unchanged during long-term somatropin treatment, mainly due to increased capacityamong patients with isolated GH deficiency. Nine months after stopping treatment, peak Vo(2) decreased by 11% from 32.8 +/- 2.5 to 29.1 +/-2.1 ml/kg/min (P < 0.05). Maximal muscular handgrip strength was not affected by treatment. Long-term GH therapy resulted in decreased respiratory exchange value (R value) at rest and during exercise (P < 0.001), suggesting a metabolic role with increased fat combustion. Restingand submaximal noradrenaline levels decreased during somatropin treatment (P < 0.05), while no effect was observed for other exercise-induced hormonal responses, including adrenaline, insulin, prolactin, renin, and ACTH. We conclude that somatropin therapy to childhood onset GH deficient adults has a favourable effect on exercise capacity and may have a potentially beneficial effect on plasma catecholamines. (C) 1998 Churchill Livingstone.

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Documento generato il 30/11/20 alle ore 16:38:17