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Titolo:
DEXTROMETHORPHAN AND PAIN AFTER TOTAL ABDOMINAL HYSTERECTOMY
Autore:
MCCONAGHY PM; MCSORLEY P; MCCAUGHEY W; CAMPBELL WI;
Indirizzi:
CRAIGAVON AREA HOSP,DEPT ANAESTHESIA,66 LURGAN RD PORTADOWN BT63 5QQ CO ARMAGH NORTH IRELAND ULSTER HOSP,DEPT ANAESTHESIA BELFAST BT16 0RH ANTRIM NORTH IRELAND
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 5, volume: 81, anno: 1998,
pagine: 731 - 736
SICI:
0007-0912(1998)81:5<731:DAPATA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NMDA RECEPTOR ANTAGONIST; ACID EAA ANTAGONISTS; RAT SPINAL-CORD; DORSAL HORN; ANTINOCICEPTIVE ACTIVITY; SECONDARY HYPERALGESIA; NEURONAL-ACTIVITY; ANALGESIC AGENTS; AFFERENT INPUT;
Keywords:
PHARMACOLOGY, DEXTROMETHORPHAN; PAIN, POSTOPERATIVE; PAIN, MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Mcconaghy et al., "DEXTROMETHORPHAN AND PAIN AFTER TOTAL ABDOMINAL HYSTERECTOMY", British Journal of Anaesthesia, 81(5), 1998, pp. 731-736

Abstract

Dextromethorphan is an N-methyl-D-aspartate (NMDA) receptor antagonist which has been shown to inhibit the development of cutaneous secondary hyperalgesia after tissue trauma. We studied 60 ASA I-II patients undergoing total abdominal hysterectomy in a randomized, double-blind, placebo-controlled study. Patients received either dextromethorphan 27mg capsules, two doses before operation and three doses in the first 24 h after operation, or placebo. Visual analogue pain scores (VAS) at24 and 48 h were assessed at rest, on coughing and on sitting up, andwere not significantly different between groups. Morphine consumptionfrom a patient-controlled analgesia (PCA) device was also not significantly different between groups. Evidence of secondary hyperalgesia was assessed with von Prey hairs 10 cm above the Pfannenstiel incision. Both groups of patients exhibited evidence of secondary hyperalgesia after 24 and 48 h but there were no significant differences between groups. There was also no difference between groups in VAS scores at 1 month.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:38:58