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Titolo:
DEPLETION OF THE NATURAL-KILLER-CELL POPULATION IN THE PERITONEUM BY AK-5 TUMOR-CELLS OVEREXPRESSING FAS-LIGAND - A MECHANISM OF IMMUNE EVASION
Autore:
KHAR A; VARALAKSHMI C; PARDHASARADHI BVV; ALI AM; KUMARI AL;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cellular immunology (Print)
fascicolo: 2, volume: 189, anno: 1998,
pagine: 85 - 91
SICI:
0008-8749(1998)189:2<85:DOTNPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; NECROSIS-FACTOR; INDUCED APOPTOSIS; ANTI-FAS; EXPRESSION; HISTIOCYTOMA; PRIVILEGE; THYMOCYTES; INDUCTION;
Keywords:
FAS-L; AK-5 TUMOR; IMMUNE ESCAPE; NK CELL FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar et al., "DEPLETION OF THE NATURAL-KILLER-CELL POPULATION IN THE PERITONEUM BY AK-5 TUMOR-CELLS OVEREXPRESSING FAS-LIGAND - A MECHANISM OF IMMUNE EVASION", Cellular immunology (Print), 189(2), 1998, pp. 85-91

Abstract

AK-5 tumor hills 100% hosts when injected ip and only 20-30% of animals die when the tumor cells are transplanted sc. Seventy percent of animals regress the subcutaneous tumor and exhibit total immunity against subsequent challenges of AK-5 cells by either route. Initially the 100% killing in ip-injected animals was attributed to the rapid growth of the tumor cells in the peritoneum thereby not giving enough time for the host immune system to mount an antitumor response. In the present report we have demonstrated overexpression of Fas-L by day 3 and day4 ascitic tumor cells which depletes the peritoneum of Fas(+) lymphocytes. In addition the effector cells from the ascites are ineffective in inducing cytotoxicity against tumor cells in vitro. However, splenocytes from animals bearing ip tumors possessed cytotoxicity against YAC-I as web as AK-5 cells. We have also shown the presence of soluble Fas-L in the ascitic fluid, which induced DNA fragmentation in Fas(+) Jurkat cells. Fas-L present in the tumor cells is able to induce apoptosis in activated lymphocytes and Jurkat cells, suggesting retention ofits biological function. These studies implicate Fas-L in the depletion of the effector cell number and inhibition of their functional activity. They also suggest differential regulation of Fas-L expression bythe tumor cells depending upon the site of transplantation. (C) 1998 Academic Press.

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Documento generato il 03/07/20 alle ore 22:33:48