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Titolo:
SPATIAL MEMORY DEFICITS IN PATIENTS WITH LESIONS TO THE RIGHT HIPPOCAMPUS AND TO THE RIGHT PARAHIPPOCAMPAL CORTEX
Autore:
BOHBOT VD; KALINA M; STEPANKOVA K; SPACKOVA N; PETRIDES M; NADEL L;
Indirizzi:
MCGILL UNIV,MONTREAL NEUROL INST,MCCONNELL BRAIN IMAGING CTR,3801 UNIV ST MONTREAL PQ H3A 2B4 CANADA UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85724 UNIV ARIZONA,ARL DIV NEURAL SYST MEMORY & AGING TUCSON AZ 85724 HOSP NA HOMOLCE,DEPT NEUROL PRAGUE 15119 CZECH REPUBLIC CHARLES UNIV,FAC MED 1,NEUROL CLIN PRAGUE 12000 CZECH REPUBLIC
Titolo Testata:
Neuropsychologia
fascicolo: 11, volume: 36, anno: 1998,
pagine: 1217 - 1238
SICI:
0028-3932(1998)36:11<1217:SMDIPW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL TEMPORAL-LOBE; FREELY-MOVING RAT; TOPOGRAPHICAL DISORIENTATION; VISUAL RECOGNITION; RHESUS-MONKEYS; IMPAIR MEMORY; HUMAN AMNESIA; PLACE; AMYGDALA; LOCATION;
Keywords:
MEDIAL TEMPORAL LOBES; NAVIGATION; SPATIAL; AMNESIA; HUMAN; RAT; HIPPOCAMPUS; PARAHIPPOCAMPAL CORTEX; ANTERIOR COLLATERAL SULCUS; TOPOGRAPHICAL MEMORY; ENVIRONMENTAL AGNOSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
V.D. Bohbot et al., "SPATIAL MEMORY DEFICITS IN PATIENTS WITH LESIONS TO THE RIGHT HIPPOCAMPUS AND TO THE RIGHT PARAHIPPOCAMPAL CORTEX", Neuropsychologia, 36(11), 1998, pp. 1217-1238

Abstract

Spatial memory tasks, performance of which is known to be sensitive to hippocampal lesions in the rat, or to medial temporal lesions in thehuman, were administered in order to investigate the effects of selective damage to medial temporal lobe structures of the human brain. Thepatients had undergone thermo-coagulation with a single electrode along the amygdalo-hippocampal axis in an attempt to alleviate their epilepsy. With this surgical technique, lesions to single medial temporal lobe structures can be carried out. The locations of the lesions were assessed by means of digital high-resolution magnetic resonance imaging and software allowing a 3-D reconstruction of the brain. A break in the collateral sulcus, dividing it into the anterior collateral sulcusand the posterior collateral sulcus is reported. This division may correspond to the end of the entorhinal/perirhinal cortex and the start of the parahippocampal cortex. The results confirmed the role of the right hippocampus in visuo-spatial memory tasks (object location, Rey-Osterrieth Figure with and without delay) and the left for verbal memory tasks (Rey Auditory Verbal Learning Task with delay). However, patients with lesions either to the right or to the left hippocampus were unimpaired on several memory tasks, including a spatial one, with a 30 min delay, designed to be analogous to the Morris water maze. Patientswith lesions to the right parahippocampal cortex were impaired on this task with a 30 min delay, suggesting that the parahippocampal cortexitself may play an important role in spatial memory. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 11/07/20 alle ore 09:55:04