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Titolo:
ANTIPHOSPHOLIPID SYNDROME - FROM PATIENTS BEDSIDE TO EXPERIMENTAL ANIMAL-MODELS AND BACK TO THE PATIENTS BEDSIDE
Autore:
ZIPOREN L; SHOENFELD Y;
Indirizzi:
CHAIM SHEBA MED CTR,DEPT MED B,AUTOIMMUNE DIS RES UNIT IL-52621 TEL HASHOMER ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL CHAIM SHEBA MED CTR,DEPT MED B,AUTOIMMUNE DIS RES UNIT IL-52621 TEL HASHOMER ISRAEL
Titolo Testata:
HEMATOLOGY AND CELL THERAPY
fascicolo: 5, volume: 40, anno: 1998,
pagine: 175 - 182
SICI:
1269-3286(1998)40:5<175:AS-FPB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ANTIPHOSPHOLIPID-SYNDROME; SYSTEMIC LUPUS-ERYTHEMATOSUS; RECURRENT FETAL LOSS; MONOCLONAL ANTICARDIOLIPIN ANTIBODY; MICE FOLLOWING IMMUNIZATION; NAIVE MICE; IDIOTYPIC NETWORK; GLYCOPROTEIN-I; GAMMA-GLOBULIN; DNA IDIOTYPE;
Keywords:
ANTIPHOSPHOLIPID SYNDROME; ANTICARDIOLIPIN ANTIBODIES; AUTOIMMUNE; BETA-2GPI; PREGNANCY FAILURE; ANIMALS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
L. Ziporen e Y. Shoenfeld, "ANTIPHOSPHOLIPID SYNDROME - FROM PATIENTS BEDSIDE TO EXPERIMENTAL ANIMAL-MODELS AND BACK TO THE PATIENTS BEDSIDE", HEM CELL TH, 40(5), 1998, pp. 175-182

Abstract

The availability of animal models of the APS has provided a rot of experimental data which might be considered in trying to unravel severalquestions concerning this complicated disease. The main clinical manifestations associated with this disorder are repeated pregnancy loss, thrombocytopenia and thrombotic events. Other manifestations have beenreported in relation to APS. However, the association with anti-phospholipid antibodies (aPL) are still uncertain. In the APS murine modelspresented here, both the Lupus-prone mice and the naive mice with induced APS, fetal resorption (parallels to embryo loss) and reduced fecundity rate were prominent features strongly associated with pathogenicaCL antibodies, making these models appropriate for investigating thehuman disease. Utilizing these models for APS have enabled to show the pathogenicity of aPL in pregnancy loss, neurological and behavioral changes, renal involvement and thrombus formation. Antiphospholipid antibodies from patients with APS, as well as natural aCL antibodies exerted pathogenic effects in naive mice, and in an in vivo thrombosis model. Several therapeutic modalities were found promising for application in the clinics. These include the antithrombotic and anticoagulant treatments using aspirin or LMWH, IL-3, or immunomodulation by high dose IVIG, specific anti-idiotypic or anti-CD4 antibodies, cyprofloxacinor bromocriptin administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:11:17