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Titolo:
IMMUNORADIOMETRIC ASSAY OF THYROGLOBULIN IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOMAS - NEED FOR THYROGLOBULIN RECOVERY TESTS
Autore:
BOURREL F; HOFF M; REGIS H; COURRIERE P; CARON P;
Indirizzi:
CHU RANGUEIL,SERV ENDOCRINOL & MALAD METAB,1 AVE J POULHES F-31054 TOULOUSE FRANCE CHU,DEPT NUCL MED TOULOUSE FRANCE ICR,DEPT RADIOIMMUNOL TOULOUSE FRANCE CHU,DEPT ENDOCRINOL TOULOUSE FRANCE
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 9, volume: 36, anno: 1998,
pagine: 725 - 730
SICI:
1434-6621(1998)36:9<725:IAOTIP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM THYROGLOBULIN; FOLLOW-UP; AUTOANTIBODIES; CANCER; ANTIBODIES; IRMA;
Keywords:
THYROGLOBULIN; IMMUNORADIOMETRIC ASSAY; AUTOANTIBODIES; DIFFERENTIATED THYROID CARCINOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
F. Bourrel et al., "IMMUNORADIOMETRIC ASSAY OF THYROGLOBULIN IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOMAS - NEED FOR THYROGLOBULIN RECOVERY TESTS", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 36(9), 1998, pp. 725-730

Abstract

As interference from thyroglobulin autoantibodies appears to have been overcome in new commercial thyroglobulin assays by the use of monoclonal antibodies, the need for thyroglobulin recovery tests became uncertain. Sera (n=45) from patients with differentiated thyroid carcinomas were selected on the basis of a thyroglobulin recovery value below 70 % in the Dynotest Tg immunoradiometric assay (Brahms) routinely usedin our laboratory. Serum thyroglobulin levels were then measured using three other commercial immunoradiometric assays: thyroglobulin ERIA (Pasteur), HTGK (Sorin) and ELSA HTG (Cis Bio International). Thyroglobulin autoantibodies were measured using the Thyrak assay (Brahms). Although many patients were thyroglobulin antibodies-negative (< 200 U/ml, n=26), most immunoradiometric assays failed to detect thyroglobulinin patients with evidence of recurrence. Low thyroglobulin values associated with low thyroglobulin recovery in thyroglobulin antibody-negative patients appear to be more biologically relevant than a single low thyroglobulin value, which can lead to lack of medical intervention. We conclude that the thyroglobulin recovery test is a prerequisite for the correct interpretation of serum thyroglobulin levels determined with immunoradiometric assays in the follow-up of thyroglobulin autoantibody-negative patients treated for differentiated thyroid carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:37:21