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Titolo:
DIETARY PECTIN WITH HIGH-VISCOSITY LOWERS PLASMA AND LIVER CHOLESTEROL CONCENTRATION AND PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITYIN HAMSTERS
Autore:
TERPSTRA AHM; LAPRE JA; DEVRIES HT; BEYNEN AC;
Indirizzi:
UNIV UTRECHT,FAC VET MED,DEPT LAB ANIM SCI,POB 80 166 NL-3508 TD UTRECHT NETHERLANDS UNIV UTRECHT,FAC VET MED,DEPT LAB ANIM SCI NL-3584 CM UTRECHT NETHERLANDS HERCULES EUROPEAN RES CTR NL-3770 AK BARNEVELD NETHERLANDS
Titolo Testata:
The Journal of nutrition
fascicolo: 11, volume: 128, anno: 1998,
pagine: 1944 - 1949
SICI:
0022-3166(1998)128:11<1944:DPWHLP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM-LIPIDS; CITRUS PECTIN; GUINEA-PIGS; BILE-ACIDS; SOLUBLE FIBER; BLOOD-LIPIDS; GUAR GUM; FED RATS; PSYLLIUM; METABOLISM;
Keywords:
HAMSTERS; DIETARY FIBER; PECTIN; CHOLESTEROL; CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A.H.M. Terpstra et al., "DIETARY PECTIN WITH HIGH-VISCOSITY LOWERS PLASMA AND LIVER CHOLESTEROL CONCENTRATION AND PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN-ACTIVITYIN HAMSTERS", The Journal of nutrition, 128(11), 1998, pp. 1944-1949

Abstract

We fed semipurified diets containing pectin with either a high or lowin vitro viscosity at a level of 3 g/100 g air-dried diet to hamstersfor 8 wk. A control group was fed cellulose and a positive control group was fed psyllium. The pectins used were a calcium-sensitive pectin(CS-pectin) that has a high viscosity and a noncalcium-sensitive pectin (NCS-pectin) that has a low viscosity. In the presence of calcium, CS-pectin has a more than 80-fold higher viscosity than NCS-pectin which offered the opportunity to investigate the possible role of viscosity in the hypolipidemic properties of pectin. The hamsters fed CS-pectin or psyllium had considerably lower plasma cholesterol concentrations (3.69 +/- 0.44 and 4.21 +/- 0.45 mmol/L, respectively, mean +/- SD, n = 14) than those fed NCS-pectin (5.03 +/- 1.15 mmol/L) or cellulose (5.72 +/- 1.04 mmol/L). Differences in total plasma cholesterol were reflected in both high density lipoprotein and very low density lipoprotein cholesterol. There was no effect of fiber on low density lipoprotein cholesterol levels. Liver cholesterol concentrations paralleled the plasma cholesterol levels and were 9.91 +/- 2.48 mu mol/g of liver for the CS-pectin group, 15.03 +/- 5.75 for the psyllium group, 17.69 +/- 10.66 for the NCS-pectin group, and 25.57 +/- 9.23 for the cellulose group. Fecal bile acid and neutral steroid excretion tended to be higher in the hamsters fed CS-pectin than in their counterparts fed NCS-pectin. The hamsters fed psyllium had significantly greater fecal excretions of bile acids than the hamsters fed cellulose, CS-pectin or NCS-pectin, whereas the excretion of fecal neutral sterols tended to be lower. Plasma cholesteryl ester transfer protein activity was significantly lower in the hamsters fed CS-pectin than in those fed NCS-pectin. The results of this study suggest that the viscosity of pectins may determine their cholesterolemic effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:56:56