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Titolo:
LOW EXPRESSION OF EXTRACELLULAR-MATRIX COMPONENTS IN RAT-BRAIN STEM REGIONS CONTAINING MODULATORY AMINERGIC NEURONS
Autore:
HOBOHM C; HARTIG W; BRAUER K; BRUCKNER G;
Indirizzi:
UNIV LEIPZIG,PAUL FLECHSIG INST BRAIN RES,JAHNALLEE 59 D-04109 LEIPZIG GERMANY UNIV LEIPZIG,PAUL FLECHSIG INST BRAIN RES D-04109 LEIPZIG GERMANY
Titolo Testata:
Journal of chemical neuroanatomy
fascicolo: 3, volume: 15, anno: 1998,
pagine: 135 - 142
SICI:
0891-0618(1998)15:3<135:LEOECI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; PARVALBUMIN-CONTAINING NEURONS; LATERODORSAL TEGMENTAL NUCLEUS; LOCUS-COERULEUS NEURONS; CAT VISUAL-CORTEX; PERINEURONAL NETS; SUBSTANTIA-NIGRA; ELECTROPHYSIOLOGICAL CHARACTERISTICS; CAT-301 IMMUNOREACTIVITY; GABAERGIC NEURONS;
Keywords:
EXTRACELLULAR MATRIX; SUBSTANTIA NIGRA; LOCUS COERULEUS; RAPHE NUCLEI; CATECHOLAMINES; SEROTONIN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C. Hobohm et al., "LOW EXPRESSION OF EXTRACELLULAR-MATRIX COMPONENTS IN RAT-BRAIN STEM REGIONS CONTAINING MODULATORY AMINERGIC NEURONS", Journal of chemical neuroanatomy, 15(3), 1998, pp. 135-142

Abstract

Extracellular matrix proteoglycans, particularly those accumulated inperineuronal nets (PNs), have been shown to form characteristic distribution patterns in cortical and subcortical regions of adult mammals. Their involvement in sustaining mechanisms that are especially related to fast activities of neurons has been discussed as one of the possible functions. The present study deals with the spatial organization of extracellular matrix proteoglycans in brain stem regions that contain aminergic neurons, such as substantia nigra, ventral tegmental area (VTA), raphe nuclei and locus coeruleus (LC). As these nuclei are known to influence brain activity by modulatory functions exerting patterns of slow electric activity, it could be expected that PNs would be absent around aminergic cells. The staining of PNs with Wisteria floribunda agglutinin (WFA) was combined with the detection of catecholaminergic neurons by tyrosine hydroxylase immunoreactivity and of serotonergic neurons by tryptophan hydroxylase (TH) immunoreactivity using double fluorescence microscopy. It was found that the catecholaminergic andserotonergic neurons in the nuclear accumulations, as well as those scattered in adjacent regions, were not ensheathed by PNs. In contrast,several non-aminergic neurons intermingled with aminergic neurons in the raphe nuclei, in the substantia nigra pars compacta (SNC) and in the VTA, as well as many cells in the reticular part of the substantia nigra, were found to be surrounded by PNs. It can be concluded from these results that the absence of PNs around aminergic brain stem neurons, also previously shown for cholinergic basal forebrain neurons, appears as a characteristic feature common to cells that exert slow modulatory functions. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/07/20 alle ore 18:13:20