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Titolo:
MECHANISM OF ACTION OF FIBRATES ON LIPID AND LIPOPROTEIN METABOLISM
Autore:
STAELS B; DALLONGEVILLE J; AUWERX J; SCHOONJANS K; LEITERSDORF E; FRUCHART JG;
Indirizzi:
INST PASTEUR,DEPT ATHEROSCLEROSE,INSERM,U325,1 RUE PROF CALMETTE F-59019 LILLE FRANCE INST PASTEUR,DEPT ATHEROSCLEROSE,INSERM,U325 F-59019 LILLE FRANCE HADASSAH UNIV HOSP,CTR RES PREVENT & TREATMENT ATHEROSCLEROSIS,DIV MED IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Circulation
fascicolo: 19, volume: 98, anno: 1998,
pagine: 2088 - 2093
SICI:
0009-7322(1998)98:19<2088:MOAOFO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATOR-ACTIVATED RECEPTOR; CORONARY-ARTERY DISEASE; APOLIPOPROTEIN-C-III; DEPENDENT DIABETES-MELLITUS; LOW-DENSITY LIPOPROTEINS; PPAR-GAMMA ACTIVATORS; MORTALITY FOLLOW-UP; HEART-DISEASE; FATTY-ACIDS; GENE-EXPRESSION;
Keywords:
APOLIPOPROTEINS; ARTERIOSCLEROSIS; FIBRATES; HYPERCHOLESTEROLEMIA; HYPERLIPOPROTEINEMIA; LIPIDS; PPAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
B. Staels et al., "MECHANISM OF ACTION OF FIBRATES ON LIPID AND LIPOPROTEIN METABOLISM", Circulation, 98(19), 1998, pp. 2088-2093

Abstract

Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL cholesterol and an increase in HDL cholesterol concentrations. Recent investigations indicate that the effects of fibrates are mediated, at least in part, through alterations in transcription of genes encoding for proteins that control lipoprotein metabolism. Fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs). The PPAR-alpha form mediates fibrate action on HDL cholesterol levels via transcriptional induction of synthesis of the major HDL apolipoproteins, apoA-I andapoA-II. Fibrates lower hepatic apoC-III production and increase lipoprotein lipase-mediated lipolysis via PPAR. Fibrates stimulate cellular fatty acid uptake, conversion to acyl-CoA derivatives, and catabolism by the beta-oxidation pathways, which, combined with a reduction in fatty acid and triglyceride synthesis, results in a decrease in VLDL production. In summary, both enhanced catabolism of triglyceride-rich particles and reduced secretion of VLDL underlie the hypotriglyceridemic effect of fibrates, whereas their effect on HDL metabolism is associated with changes in HDL apolipoprotein expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:01:45