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Titolo:
BIODISTRIBUTION AND KINETICS OF NASAL CARBON-11-TRIAMCINOLONE ACETONIDE
Autore:
BERRIDGE MS; HEALD DL; MUSWICK GJ; LEISURE GP; VOELKER KW; MIRALDI F;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,DIV RADIOL,11100 EUCLIDAVE CLEVELAND OH 44106 RHONE POULENC RORER PHARMACEUT INC,MED AFFAIRS COLLEGEVILLE PA 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 11, volume: 39, anno: 1998,
pagine: 1972 - 1977
SICI:
0161-5505(1998)39:11<1972:BAKONC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIAMCINOLONE ACETONIDE; ALLERGIC RHINITIS; SPRAY;
Keywords:
PET; INHALER; NASAL; BIODISTRIBUTION; STEROID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Berridge et al., "BIODISTRIBUTION AND KINETICS OF NASAL CARBON-11-TRIAMCINOLONE ACETONIDE", The Journal of nuclear medicine, 39(11), 1998, pp. 1972-1977

Abstract

PET is a technique with a strong potential for use in drug evaluationand development. In particular, the distribution and pharmacokineticsof locally administered drugs may be advantageously explored noninvasively using labeled compounds. This pilot study was performed to demonstrate the effectiveness of PET for drug development and to determine the human biodistribution and kinetics of triamcinolone acetonide, labeled with C-11, formulated and nasally administered as Nasacort(R) AQ nasal inhalant. Methods: Carbon-11-labeled triamcinolone acetonide wasformulated as the commercial product, and PET scans of the heads of four volunteers were performed in a vertical orientation. Region-of-interest analysis with MRI coregistration was used to analyze the distribution and kinetics in nasal tissues. Results: Deposition of the majority of the dose on target tissues was immediate. Penetration into sinuses was observed. There was moderate redistribution and slow migration of the drug through nasal passages to the throat. Significant amounts of the drug remained in target regions for several hours. Conclusion: PET is an effective means to determine local drug distribution and kinetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:13:28