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Titolo:
NO ASSOCIATION BETWEEN THE SEROTONIN TRANSPORTER-LINKED PROMOTER REGION POLYMORPHISM AND EITHER SCHIZOPHRENIA OR DENSITY OF THE SEROTONIN TRANSPORTER IN HUMAN HIPPOCAMPUS
Autore:
NAYLOR L; DEAN B; PEREIRA A; MACKINNON A; KOUZMENKO A; COPOLOV D;
Indirizzi:
MENTAL HLTH RES INST,MOL SCHIZOPHRENIA DIV,REBECCA L COOPER RES LABS,LOCKED BAG 11 PARKVILLE VIC 3052 AUSTRALIA MENTAL HLTH RES INST,MOL SCHIZOPHRENIA DIV,REBECCA L COOPER RES LABS PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT PHARMACOL PARKVILLE VIC 3052 AUSTRALIA MONASH UNIV,DEPT PSYCHOL MED CLAYTON VIC 3168 AUSTRALIA
Titolo Testata:
Molecular medicine (Cambridge, Mass.)
fascicolo: 10, volume: 4, anno: 1998,
pagine: 671 - 674
SICI:
1076-1551(1998)4:10<671:NABTST>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFECTIVE-DISORDERS; H-3 PAROXETINE; GENE; SUSCEPTIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L. Naylor et al., "NO ASSOCIATION BETWEEN THE SEROTONIN TRANSPORTER-LINKED PROMOTER REGION POLYMORPHISM AND EITHER SCHIZOPHRENIA OR DENSITY OF THE SEROTONIN TRANSPORTER IN HUMAN HIPPOCAMPUS", Molecular medicine (Cambridge, Mass.), 4(10), 1998, pp. 671-674

Abstract

Background: Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disorder, depression, and Alzheimer's disease. Moreover, the heterozygous long form of the 5-HTTLPR has been associated with increased levels of mRNA for the serotonin transporter (5-HTT) and increased serotonin uptake in lymphoblastic cell lines. This study attempts to determine whether there is an association between 5-HTTLPR genotype and schizophrenia or the binding of [H-3]paroxetine to the human hippocampal 5-HTT. Materials and Methods: DNA from the cerebellum from 58 schizophrenic and 62 control subjects was used to genotype the 5-HTTLPR. Inaddition, the relationship between 5-HTTLPR genotype and the affinityand density of [H-3]paroxetine binding to the hippocampal 5-HTT was assessed. Results: There were no associations between 5-HTTLPR allotypeor genotype and/or the parameters of [H-3]paroxetine binding to the hippocampal 5-HTT. Conclusions: Our data suggest that 5-HTTLPR genotypeneither confers an increased susceptibility for schizophrenia nor dictates the expression of the 5-HTT in the human hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 17:47:40