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Titolo:
CAN EXPERIMENTAL CONDITIONS EXPLAIN THE DISCREPANCY OVER GLUTAMATE STIMULATION OF AEROBIC GLYCOLYSIS
Autore:
HERTZ L; SWANSON RA; NEWMAN GC; MARRIF H; JUURLINK BHJ; PENG LA;
Indirizzi:
UNIV SASKATCHEWAN,DEPT PHARMACOL,HLTH SCI BLDG SASKATOON SK S7N 5E5 CANADA VAMC,DEPT NEUROL SAN FRANCISCO CA 00000 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94143 VAMC,DEPT NEUROL NORTHPORT NY 00000 SUNY STONY BROOK STONY BROOK NY 11794 UNIV SASKATCHEWAN,DEPT ANAT & CELL BIOL SASKATOON SK CANADA
Titolo Testata:
Developmental neuroscience
fascicolo: 4-5, volume: 20, anno: 1998,
pagine: 339 - 347
SICI:
0378-5866(1998)20:4-5<339:CECETD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ENERGY-METABOLISM; EXCITATORY AMINO-ACIDS; GLUCOSE-UTILIZATION; PRIMARY CULTURES; ASTROCYTES; ACTIVATION; RELEVANCE; ASTROGLIA; NEURONS; ATPASE;
Keywords:
ANOXIA; ASTROCYTES; DEOXYGLUCOSE; DEOXYGLUCOSE-6-PHOSPHATE; GLUCOSE UTILIZATION; GLUTAMATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
L. Hertz et al., "CAN EXPERIMENTAL CONDITIONS EXPLAIN THE DISCREPANCY OVER GLUTAMATE STIMULATION OF AEROBIC GLYCOLYSIS", Developmental neuroscience, 20(4-5), 1998, pp. 339-347

Abstract

Uncertainty reigns over whether or not glutamate uptake in astrocytesleads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter,but also because it has been postulated that glutamate-induced stimulation of glycolysis links brain excitation with activation of energy production. The effect of glutamate on deoxyglucose utilization in cultured rat and mouse astrocytes grown in different media and incubated under various conditions during the deoxyglucose assay has, therefore, been studied. Under most conditions, no stimulation occurred but rather a decrease in deoxyglucose utilization during exposure to glutamate;under certain conditions, the contribution of non-metabolized deoxyglucose to the intracellular C-14 signal was significant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:10:07