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Titolo: STH1P, A SACCHAROMYCES-CEREVISIAE SNF2P SWI2P HOMOLOG, IS AN ESSENTIAL ATPASE IN RSC AND DIFFERS FROM SNF/SWI IN ITS INTERACTIONS WITH HISTONES AND CHROMATIN-ASSOCIATED PROTEINS/
Autore: DU J; NASIR I; BENTON BK; KLADDE MP; LAURENT BC;
- Indirizzi:
- SUNY HLTH SCI CTR,MORSE INST MOL GENET,450 CLARKSON AVE,BOX 44 BROOKLYN NY 11203 SUNY HLTH SCI CTR,MORSE INST MOL GENET BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL BROOKLYN NY 11203 ROCKEFELLER UNIV NEW YORK NY 10021 PENN STATE UNIV,DEPT BIOCHEM & MOL BIOL UNIVERSITY PK PA 16802
- Titolo Testata:
- Genetics
fascicolo: 3,
volume: 150,
anno: 1998,
pagine: 987 - 1005
- SICI:
- 0016-6731(1998)150:3<987:SASSSH>2.0.ZU;2-3
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- CELL-CYCLE ARREST; UPSTREAM ACTIVATING SEQUENCE; NUCLEOSOME REMODELING FACTOR; YEAST SWI/SNF COMPLEX; SWI-SNF COMPLEX; BUDDING YEAST; TRANSCRIPTIONAL ACTIVATORS; BINDING PROTEIN; IN-VIVO; MULTISUBUNIT COMPLEX;
- Tipo documento:
- Review
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 105
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- J. Du et al., "STH1P, A SACCHAROMYCES-CEREVISIAE SNF2P SWI2P HOMOLOG, IS AN ESSENTIAL ATPASE IN RSC AND DIFFERS FROM SNF/SWI IN ITS INTERACTIONS WITH HISTONES AND CHROMATIN-ASSOCIATED PROTEINS/", Genetics, 150(3), 1998, pp. 987-1005
Abstract
The essential Sth1p is the protein most closely related to the conserved Snf2p/Swi2p in Saccharomyces cerevisiae. Sth1p purified from yeasthas a DNA-stimulated ATPase activity required for its function in vivo. The finding that Sth1p is a component of a multiprotein complex capable of ATP-dependent remodeling of the structure of chromatin (RSC) in vitro, suggests that it provides RSC with ATP hydrolysis activity. Three sth1 temperature-sensitive mutations map to the highly conserved ATPase/helicase domain and have cell cycle and non-cell cycle phenotypes, suggesting multiple essential roles for Sth1p. The Sth1p bromodomain is required for wild-type function; deletion mutants lacking portions of this region are thermosensitive and arrest with highly elongatedbuds and 2C DNA content, indicating perturbation of a unique function. The pleiotropic growth defects of sth1-ts mutants imply a requirement for Sthlp in a general cellular process that affects several metabolic pathways. Significantly, an sth1-ts allele is synthetically sick orlethal with previously identified mutations in histones and chromatinassembly genes that suppress snf/swi, suggesting that RSC interacts differently with chromatin than Snf/Swi. These results provide a framework for understanding the ATP-dependent RSC function in modeling chromatin and its connection to the cell cycle.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:08:13