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Titolo:
ALTERATIONS OF BENZODIAZEPINE RECEPTORS IN TYPE-II ALCOHOLIC SUBJECTSMEASURED WITH SPECT AND [I-123] IOMAZENIL
Autore:
ABIDARGHAM A; KRYSTAL JH; ANJILVEL S; SCANLEY BE; ZOGHBI S; BALDWIN RM; RAJEEVAN N; ELLIS S; PETRAKIS IL; SEIBYL JP; CHARNEY DS; LARUELLE M; INNIS RB;
Indirizzi:
NEW YORK STATE PSYCHIAT INST & HOSP,UNIT 28,722 W 168TH ST NEW YORK NY 10032 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 00000 YALE UNIV,SCH MED,DEPT RADIOL NEW HAVEN CT 00000 VA CONNECTICUT HEALTHCARE SYST,VA YALE ALCOHOLISM RES CTR W HAVEN CT 00000 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PSYCHIAT NEW YORK NY 00000
Titolo Testata:
The American journal of psychiatry
fascicolo: 11, volume: 155, anno: 1998,
pagine: 1550 - 1555
SICI:
0002-953X(1998)155:11<1550:AOBRIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBUNIT MESSENGER-RNAS; I-123 IOMAZENIL; ETHANOL; BRAIN; WITHDRAWAL; ABUSERS; CORTEX; BINDING; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A. Abidargham et al., "ALTERATIONS OF BENZODIAZEPINE RECEPTORS IN TYPE-II ALCOHOLIC SUBJECTSMEASURED WITH SPECT AND [I-123] IOMAZENIL", The American journal of psychiatry, 155(11), 1998, pp. 1550-1555

Abstract

Objective: Alterations in cortical benzodiazepine receptor density have been described in postmortem and in vivo studies of alcoholic subjects. The authors attempted to replicate these findings using single photon emission computed tomography and the benzodiazepine receptor radiotracer [I-123]iomazenil. Method: They measured the distribution volume of benzodiazepine receptors in 11 recently detoxified patients with type II alcoholism and 11 healthy comparison subjects. The tracer was given as a bolus followed by a continuous infusion to achieve sustained binding equilibrium at the benzodiazepine receptors. Data were analyzed by using a region of interest method (regions of interest were identified on coregistered magnetic resonance imaging scans) and by a pixel-by-pixel method (distribution volume maps were analyzed with statistical parametric mapping for between-group differences). Results: The region of interest analysis revealed that alcoholic patients had significantly lower benzodiazepine distribution volume than comparison subjects in the frontal, anterior cingulate, and cerebellar cortices. Statistical parametric mapping revealed two large excursions in which the distribution volume in alcoholic patients was significantly lower thanin comparison subjects: the anterior cingulate, extending into the right middle frontal gyrus, and the left occipital cortex. Conclusions: Benzodiazepine receptor distribution volume is significantly lower in several cortical regions and the cerebellum in alcoholic subjects thanin healthy comparison subjects. These results are consistent with previous reports and might indicate either a toxic effect of alcoholism on benzodiazepine receptors or a vulnerability factor for developing alcoholism.

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Documento generato il 18/01/20 alle ore 07:34:51