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Titolo:
REDUCED CENTRAL SEROTONIN TRANSPORTERS IN ALCOHOLISM
Autore:
HEINZ A; RAGAN P; JONES DW; HOMMER D; WILLIAMS W; KNABLE MB; GOREY JG; DOTY L; GEYER C; LEE KS; COPPOLA R; WEINBERGER DR; LINNOILA M;
Indirizzi:
RUHR UNIV BOCHUM,ST JOSEF HOSP,DEPT NEUROL,GUDRUNSTR 56 D-44791 BOCHUM GERMANY NIMH,ST ELIZABETHS HOSP,CTR NEUROSCI,CLIN BRAIN DISORDERS BRANCH WASHINGTON DC 20032 NIAAA,DIV INTRAMURAL CLIN BIOL RES,CLIN STUDIES LAB BETHESDA MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 11, volume: 155, anno: 1998,
pagine: 1544 - 1549
SICI:
0002-953X(1998)155:11<1544:RCSTIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-HUMAN SUBJECTS; I-123 BETA-CIT; IN-VIVO; DOPAMINE TRANSPORTER; SYNAPTIC DOPAMINE; MESSENGER-RNA; BINDING; ETHANOL; BRAIN; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A. Heinz et al., "REDUCED CENTRAL SEROTONIN TRANSPORTERS IN ALCOHOLISM", The American journal of psychiatry, 155(11), 1998, pp. 1544-1549

Abstract

Objective: Dysfunction of monoamine uptake mechanisms has been implicated in the pathogenesis of alcohol dependence. The authors explored whether serotonergic dysfunction is associated with anxiety and depression, which increase the risk of relapse in alcoholics. Method: The availability of serotonin and dopamine transporters in 22 male alcoholicsand 13 healthy male volunteers was measured with the use of [I-123]beta-CIT and single photon emission computed tomography, and psychopathological correlates were assessed. Results: A significant reduction (a mean of about 30%) in the availability of brainstem serotonin transporters was found in the alcoholics, which was significantly correlated with lifetime alcohol consumption and with ratings of depression and anxiety during withdrawal. Conclusions: The findings support the hypothesis of serotonergic dysfunction in alcoholism and in withdrawal-emergent depressive symptoms.

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Documento generato il 21/09/20 alle ore 06:10:09