Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVALUATION OF GENTAMICIN PHARMACOKINETICS AND DOSING PROTOCOLS IN 195NEONATES
Autore:
MURPHY JE; AUSTIN ML; FRYE RF;
Indirizzi:
UNIV ARIZONA,COLL PHARM,DEPT PHARM PRACTICE & SCI,POB 210207 TUCSON AZ 85721 SAFEWAY PHARM PHOENIX AZ 00000 UNIV PITTSBURGH,SCH PHARM PITTSBURGH PA 00000
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 21, volume: 55, anno: 1998,
pagine: 2280 - 2288
SICI:
1079-2082(1998)55:21<2280:EOGPAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTCONCEPTIONAL AGE; INFANTS;
Keywords:
AGE; AMINOGLYCOSIDES; BLOOD LEVELS; DOSAGE SCHEDULES; DRUGS, BODY DISTRIBUTION; EXCRETION; GENTAMICIN; HALF-LIFE; PEDIATRICS; PHARMACOKINETICS; PROTOCOLS; WEIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Murphy et al., "EVALUATION OF GENTAMICIN PHARMACOKINETICS AND DOSING PROTOCOLS IN 195NEONATES", American journal of health-system pharmacy, 55(21), 1998, pp. 2280-2288

Abstract

Gentamicin pharmacokinetics and dosing protocols in neonates were studied. Demographic and pharmacokinetic data on 202 neonates treated with gentamicin at a 500-bed medical center were collected over a three-year period. Administered doses, gentamicin concentration measurements,and recorded times were used to calculate each patient's clearance, volume of distribution, elimination rate constant, and half-life. The performance of 15 dosing protocols, including 6 previously published ones and 9 developed on the basis of the study, was evaluated using the pharmacokinetic data. Of the 202 patients, 195 were included in the analysis. The mean +/-S.D. clearance, volume of distribution, elimination rate constant, and half-life were 0.047 +/- 0.015 L/hr/kg, 0.45+/-0.11 L/kg, 0.107 +/- 0.032 L/hr, and 7.19 +/- 2.64 hours, respectively. Weight, urine output, gestational age, and postconceptional age (PCA) had the highest correlation with the pharmacokinetic values. Blood urea nitrogen concentration (BUN) and Apgar score were poor predictors ofthe pharmacokinetic values. There were no significant differences among patient subsets based on race and BUN, but subset analysis based onPCA did indicate significant differences. In simulations, the protocols based on the study patients tended to perform better than the literature protocols, with all but three achieving therapeutic goals in 75%or more of the neonates. Of the published protocols, Murphy and Carter's produced the greatest percentage of neonates with peaks from 5 to 10 mg/L and troughs of <2 mg/L. The devised protocols tended to perform poorly in producing troughs between 1 and 2 mg/L, yet performed comparatively well in providing therapeutic peaks from 5 to 10 mg/L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:20:54