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Titolo:
CONSIDERATIONS FOR LONG-TERM USE OF PROTON-PUMP INHIBITORS
Autore:
GARNETT WR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,SCH PHARM,BOX 980533 RICHMOND VA 23298
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 21, volume: 55, anno: 1998,
pagine: 2268 - 2279
SICI:
1079-2082(1998)55:21<2268:CFLUOP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; ENTEROCHROMAFFIN-LIKE-CELL; SERUM GASTRIN-LEVELS; STEADY-STATE PHARMACOKINETICS; ZOLLINGER-ELLISON SYNDROME; MULTIPLE-DOSE OMEPRAZOLE; RANDOMIZED DOUBLE-BLIND; HUMAN-COLON-CANCER; COLORECTAL NEOPLASIA; BACTERIAL OVERGROWTH;
Keywords:
ACHLORHYDRIA; DOSAGE SCHEDULES; DRUG INTERACTIONS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DRUGS; NUTRITION DISORDERS; PEPTIC ULCER; TOXICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
165
Recensione:
Indirizzi per estratti:
Citazione:
W.R. Garnett, "CONSIDERATIONS FOR LONG-TERM USE OF PROTON-PUMP INHIBITORS", American journal of health-system pharmacy, 55(21), 1998, pp. 2268-2279

Abstract

The safety of proton-pump inhibitors (PPIs) for long-term use is reviewed. PPIs are being used with increasing frequency to inhibit secretion of gastric acid in order to treat acid-related disorders such as gastroesophageal reflux disease and peptic ulcer disease. Some patients may require long-term acid suppressive treatment to control the symptoms of their disease, which raises questions about the long-term safetyof PPIs. A thorough literature search was conducted, and the clinicalconsequences of sustained hypergastrinemia induced by all antisecretory therapy, the consequences of atrophic gastritis in patients infected with Helicobacter pylori, the effects of hypochlorhydria on bacterial overgrowth and nutrient absorption, and possible interactions of PPIs with other drugs were identified as areas of concern with long-term use of PPIs. Short- and longterm studies showed that PPIs have a wide safety margin and a favorable adverse-event profile with few drug interactions. Available data support the short- and long-term safety of PPIs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:55:13