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Titolo:
VASCULAR REACTIVITY IS IMPAIRED IN GENETIC FEMALES TAKING HIGH-DOSE ANDROGENS
Autore:
MCCREDIE RJ; MCCROHON JA; TURNER L; GRIFFITHS KA; HANDELSMAN DJ; CELERMAJER DS;
Indirizzi:
ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL,MISSENDEN RD CAMPERDOWN NSW 2050 AUSTRALIA ROYAL PRINCE ALFRED HOSP,DEPT CARDIOL CAMPERDOWN NSW 2050 AUSTRALIA ROYAL PRINCE ALFRED HOSP,HEART RES INST CAMPERDOWN NSW 2050 AUSTRALIA ROYAL PRINCE ALFRED HOSP,ANDROL UNIT CAMPERDOWN 2050 NSW AUSTRALIA UNIV SYDNEY,DEPT MED SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 5, volume: 32, anno: 1998,
pagine: 1331 - 1335
SICI:
0735-1097(1998)32:5<1331:VRIIIG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; POSTMENOPAUSAL WOMEN; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; DEPENDENT DILATATION; CIGARETTE-SMOKING; ESTROGEN; TESTOSTERONE; ARTERIES; AORTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Mccredie et al., "VASCULAR REACTIVITY IS IMPAIRED IN GENETIC FEMALES TAKING HIGH-DOSE ANDROGENS", Journal of the American College of Cardiology, 32(5), 1998, pp. 1331-1335

Abstract

Objective. To assess the vascular effects of high dose androgen treatment in genetic females. Background. Male gender is an independent risk factor for coronary artery disease, suggesting either a protective effect of estrogens and/or a deleterious effect of androgens. We have recently demonstrated that androgen deprivation is associated with enhanced vascular reactivity in adult men, however, the effects of androgen excess on vascular function in humans has not been reported previously. Methods. We studied vascular reactivity in two groups of genetic females: 12 female to-male transsexuals receiving longterm high-dose androgens, and 12 healthy female control subjects, matched for age and smoking history. Using external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (leading to flow-mediated dilatation [FMD], which depends on normal endothelial function) and after sublingual nitroglycerin (NTG), an endothelium-independent dilator. Results. Testosterone levels were higher (15.2 +/- 8.7 vs. 1.9 /- 1.3 mmol/L, p < 0.001) and high density lipoprotein cholesterol levels were lower (1.2 +/- 0.2 vs, 1.6 +/- 0.4 mmol/L, p = 0.02) in the transsexuals compared with the control subjects. In each group, nine of 12 subjects were current or ex-smokers, leading to impaired FMD in both groups (5.1 +/- 3.7% in the transsexuals vs. 6.9 +/- 4.1% in controls, p = 0.28). The NTG response was significantly decreased in the transsexuals (15.9 +/- 4.9% vs. 22 +/- 5.8% in controls, p = 0.01), independent of the effects of age, cholesterol or vessel size. Conclusions. Long term treatment with high-dose androgens is associated with impaired vascular reactivity in genetic females, consistent with a deleterious effect of androgen excess on arterial physiology. (C) 1998 by theAmerican College of Cardiology.

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Documento generato il 08/07/20 alle ore 08:01:25