Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITION OF CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2 - ANALYSIS OF IN-VITRO TEST SYSTEMS AND THEIR CLINICAL RELEVANCE
Autore:
PAIRET M;
Indirizzi:
BOEHRINGER INGELHEIM PHARMA KG,ATEMWEGSFORSCH,DEPT PULM RES,BINGER STR 173 D-55216 INGELHEIM GERMANY
Titolo Testata:
Journal of clinical rheumatology
fascicolo: 5, volume: 4, anno: 1998, supplemento:, S
pagine: 17 - 25
SICI:
1076-1608(1998)4:5<17:IOCAC->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN-G/H SYNTHASE-1; SELECTIVE-INHIBITION; MESSENGER-RNA; DIFFERENTIAL INHIBITION; HEALTHY-VOLUNTEERS; SYNOVIAL-FLUID; IN-VITRO; COX-2; MECHANISM;
Keywords:
NSAIDS; CYCLOOXYGENASE INHIBITOR; IN VITRO ASSAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Pairet, "INHIBITION OF CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2 - ANALYSIS OF IN-VITRO TEST SYSTEMS AND THEIR CLINICAL RELEVANCE", Journal of clinical rheumatology, 4(5), 1998, pp. 17-25

Abstract

Numerous in vitro assay systems have been developed for testing and comparing the relative inhibitory activities of nonsteroidal anti-inflammatory drugs (NSAIDs) against cyclooxygenase (COX)-1 and COX-2, the two COX isoforms responsible for prostaglandin biosynthesis. Despite variability among these systems, which precludes direct comparison of data, analysis of the ratio of inhibition of COX-2 to COX-1 by NSAIDs suggests that inhibitors can be classified based on their COX selectivity. Standard NSAIDs can be considered nonselective; compounds such as meloxicam, nimesulide, and etodolac can be classified as preferential COX-2 inhibitors; other compounds currently under development are highly specific for COX-2. Although in vitro systems are important in characterizing activity, the clinical relevance of these data should be carefully considered. Models based on in vitro data can be constructed and may be compared with, but are no substitute for, in vivo results when they become available.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:20:45