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Titolo:
AN MBOI 2-ALLELE POLYMORPHISM MAY IMPLICATE THE HUMAN RENIN GENE IN PRIMARY HYPERTENSION
Autore:
FROSSARD PM; LESTRINGANT GG; ELSHAHAT YI; JOHN A; OBINECHE EN;
Indirizzi:
FAC MED & HLTH SCI,DEPT PATHOL,POB 17666 AL AIN U ARAB EMIRATES TAWAM HOSP,DEPT INTERNAL MED AL AIN U ARAB EMIRATES CENT HOSP,NEPHROL UNIT ABU ZABY U ARAB EMIRATES FAC MED & HLTH SCI,DEPT INTERNAL MED AL AIN U ARAB EMIRATES
Titolo Testata:
Hypertension research
fascicolo: 3, volume: 21, anno: 1998,
pagine: 221 - 225
SICI:
0916-9636(1998)21:3<221:AM2PMI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISMS; BLOOD-PRESSURE REGULATION; GULF ARAB POPULATION; ANGIOTENSIN SYSTEM; ASSOCIATION; LOCUS; FREQUENCY; LINKAGE; TRAITS; RATS;
Keywords:
GENETICS; HYPERTENSION; POLYMERASE CHAIN REACTION; RENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Frossard et al., "AN MBOI 2-ALLELE POLYMORPHISM MAY IMPLICATE THE HUMAN RENIN GENE IN PRIMARY HYPERTENSION", HYPERTENS R, 21(3), 1998, pp. 221-225

Abstract

As a key enzyme of the renin-angiotensin-aldosterone system, the renin gene (REN) is a good candidate quantitative trait locus that may be implicated in the molecular etiology of essential hypertension. Among mixed reports on the subject, a REN MboI restriction fragment length polymorphism has been shown to be significantly associated with a family history of hypertension in a Japanese population. We show here that the REN MboI dimorphic site is located in the ninth intron of the gene, and we describe a polymerase chain reaction-based assay for detection of this site. We investigated MboI genotype distributions in 331 hypertensive and 279 normotensive subjects from the United Arab Emirates (UAE), a genetically homogeneous ethnic population with no history of smoking or alcohol consumption. A statistically significant association was found between alleles on which the MboI site is present and clinical diagnosis of essential hypertension, indicating that 1) the presence of the MboI site is a marker for susceptibility to hypertension inthe UAE (the associated odds ratio is 3.16); and 2) variations of theREN (or of a nearby) gene that may be in linkage disequilibrium with this marker play a role in the development of essential hypertension in the UAE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:46:41