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Titolo:
INHIBITORY EFFECTS OF AN ANTIESTROGEN, TOREMIFENE ON THE PHORBOL ESTER-INDUCED ADHESIVE CAPACITY OF BREAST-CARCINOMA CELLS
Autore:
MAEMURA M; IINO Y; HORIGUCHI J; TAKEI H; HORII Y; KOIBUCHI Y; YOKOE T; TAKEYOSHI I; OHWADA S; MORISHITA Y;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT SURG 2,3-39-15 SHOWA MACHI GUNMA 3718511 JAPAN GUNMA UNIV,SCH MED,DEPT EMERGENCY & CRIT CARE MED GUNMA 3718511 JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 5, volume: 13, anno: 1998,
pagine: 981 - 985
SICI:
1019-6439(1998)13:5<981:IEOAAT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CANCER-CELLS; MELANOMA-CELLS; INTEGRIN RECEPTOR; TUMOR PROMOTER; EXPRESSION; TAMOXIFEN; LAMININ; GROWTH; METASTASIS;
Keywords:
BREAST CANCER; ANTIESTROGEN; CELLULAR ADHESION; PKC; ALPHA-2-BETA-1 INTEGRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Maemura et al., "INHIBITORY EFFECTS OF AN ANTIESTROGEN, TOREMIFENE ON THE PHORBOL ESTER-INDUCED ADHESIVE CAPACITY OF BREAST-CARCINOMA CELLS", International journal of oncology, 13(5), 1998, pp. 981-985

Abstract

Previous studies have revealed that protein kinase C (PKC) is responsible for malignant progression. In the present study, we investigated the potent inhibitory effects of an antiestrogen, toremifene, on PKC-mediated cellular adhesion. A phorbol ester, phorbol 12-myristate 13-acetate (PMA), significantly enhanced alpha 2 beta 1 integrin-dependent adhesion of MCF-7 breast carcinoma cells. This PMA-induced adhesion was partially inhibited by incubating cells with toremifene prior to PMAexposure in a time- and dose-dependent manner. FACS analysis demonstrated that the PMA-induced alpha 2 beta 1-dependent cellular adhesion was accompanied with elevated expression of alpha 2 and beta 1 integrinsubunit on the cell surface. However, toremifene did not affect the elevated expression levels of these integrins but rather the avidity ofalpha 2 beta 1 integrin. We concluded that toremifene inhibited cellular adhesion activated by PMA, probably through mechanism which inhibits PKC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:19:54