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Titolo:
MULTIFUNCTIONAL POTENTIAL OF THE PLASMINOGEN ACTIVATION SYSTEM IN TUMOR INVASION AND METASTASIS (REVIEW)
Autore:
REUNING U; MAGDOLEN V; WILHELM O; FISCHER K; LUTZ V; GRAEFF H; SCHMITT M;
Indirizzi:
TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,FRAUENKLIN,ISMANINGER STR 22 D-81675 MUNICH GERMANY
Titolo Testata:
International journal of oncology
fascicolo: 5, volume: 13, anno: 1998,
pagine: 893 - 906
SICI:
1019-6439(1998)13:5<893:MPOTPA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BREAST-CANCER; ADVANCED OVARIAN-CANCER; UROKINASE-RECEPTOR INTERACTION; SUPERFICIAL BLADDER-CANCER; AMINO-TERMINAL FRAGMENT; RESECTED GASTRIC-CANCER; GROWTH-FACTOR ACTIVITY; HUMAN EPIDERMAL-CELLS; NF-KAPPA-B; COLORECTAL-CANCER;
Keywords:
INVASION; METASTASIS; PLASMINOGEN ACTIVATOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
207
Recensione:
Indirizzi per estratti:
Citazione:
U. Reuning et al., "MULTIFUNCTIONAL POTENTIAL OF THE PLASMINOGEN ACTIVATION SYSTEM IN TUMOR INVASION AND METASTASIS (REVIEW)", International journal of oncology, 13(5), 1998, pp. 893-906

Abstract

Tumor cell migration and invasion into the surrounding tissue depend-on the invasive capacity of cells leading to the loosening of cell-cell and cell-substratum contacts via cell surface associated proteolyticenzyme systems. Plasmin is one of the enzymes involved in these complex events. It is generated by the cleavage of the proenzyme plasminogen upon the action of the urokinase-type plasminogen activator (uPA). uPA is synthesized and secreted by tumor cells and normal cells and interacts with a specific cell surface receptor (uPAR) thereby focalizingenzymatic activity to the cell surface. The activity of uPA is controlled by plasminogen activator inhibitors type-1 and type-2. A strong statistically independent prognostic impact has been attributed to uPA and its inhibitor PAI-1 in a variety of malignancies. Besides its proteolytic activity, uPA in concert with uPAR exert biological effects characteristic for molecules with signal transducing properties including chemotaxis, migration/invasion, adhesion, and mitogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:06:50