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Titolo:
THE GROWTH-HORMONE SECRETAGOGUE KP-102-INDUCED STIMULATION OF FOOD-INTAKE IS MODIFIED BY FASTING, RESTRAINT STRESS, AND SOMATOSTATIN IN RATS
Autore:
SHIBASAKI T; YAMAUCHI N; TAKEUCHI K; ISHII S; SUGIHARA H; WAKABAYASHI I;
Indirizzi:
NIPPON MED COLL,DEPT PHYSIOL,BUNKYO KU,1-1-5 SENDAGI TOKYO 1138602 JAPAN NIPPON MED COLL,DEPT MED,BUNKYO KU TOKYO 1138602 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 255, anno: 1998,
pagine: 9 - 12
SICI:
0304-3940(1998)255:1<9:TGSKSO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARCUATE NUCLEUS; NEUROPEPTIDE-Y; PITUITARY; HEXAPEPTIDE; INDUCTION; INJECTION; RECEPTOR; INVITRO; RELEASE;
Keywords:
GROWTH HORMONE SECRETAGOGUE; KP-102; CENTRAL NERVOUS SYSTEM ACTION; FEEDING BEHAVIOR; FASTING; RESTRAINT STRESS; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T. Shibasaki et al., "THE GROWTH-HORMONE SECRETAGOGUE KP-102-INDUCED STIMULATION OF FOOD-INTAKE IS MODIFIED BY FASTING, RESTRAINT STRESS, AND SOMATOSTATIN IN RATS", Neuroscience letters, 255(1), 1998, pp. 9-12

Abstract

The effects of fasting, restraint stress, and intracerebroventricular(i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats. KP-102-induced stimulation of food intake was observed in freely-fed ratsbut not in 24-h starved rats. A 90 min period of restraint stress decreased food intake, and i.c.v. administration of KP-102 counteracted the suppressive effect of restraint on food intake. ICV administration of somatostatin partially attenuated the KP-102-induced stimulation offood intake in freely-fed rats, while somatostatin itself did not change food intake. These results suggest that the stimulatory effect of KP-102 on feeding behavior is evident in freely-fed rats but not in starved rats, and that the effect of KP-102 is counteracted or attenuated by stress or somatostatin. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:41:41