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Titolo:
ALPHA-7 NICOTINIC RECEPTOR SUBUNITS ARE NOT NECESSARY FOR HIPPOCAMPAL-DEPENDENT LEARNING OR SENSORIMOTOR GATING - A BEHAVIORAL CHARACTERIZATION OF ACRA7-DEFICIENT MICE
Autore:
PAYLOR R; NGUYEN M; CRAWLEY JN; PATRICK J; BEAUDET A; ORRURTREGER A;
Indirizzi:
BAYLOR COLL MED,DEPT MOL & HUMAN GENET HOUSTON TX 77030 NIMH,EXPT THERAPEUT BRANCH,SECT BEHAV NEUROPHARMACOL BETHESDA MD 20892 BAYLOR COLL MED,DIV NEUROSCI HOUSTON TX 77030 HOWARD HUGHES MED INST HOUSTON TX 77030 TEL AVIV SOURASKY MED CTR,INST GENET IL-64239 TEL AVIV ISRAEL
Titolo Testata:
Learning & memory
fascicolo: 4-5, volume: 5, anno: 1998,
pagine: 302 - 316
SICI:
1072-0502(1998)5:4-5<302:ANRSAN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; INBRED MOUSE STRAINS; AUDITORY-EVOKED RESPONSE; IN-VIVO CHARACTERIZATION; TRAIT LOCI ANALYSES; ACETYLCHOLINE-RECEPTOR; PREPULSE INHIBITION; SPATIAL MEMORY; ANIMAL-MODELS; SINGLE-GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
R. Paylor et al., "ALPHA-7 NICOTINIC RECEPTOR SUBUNITS ARE NOT NECESSARY FOR HIPPOCAMPAL-DEPENDENT LEARNING OR SENSORIMOTOR GATING - A BEHAVIORAL CHARACTERIZATION OF ACRA7-DEFICIENT MICE", Learning & memory, 5(4-5), 1998, pp. 302-316

Abstract

The alpha 7 nicotinic acetylcholine receptor (nAChR) subunit is abundantly expressed In. the hippocampus and contributes to hippocampal cholinergic synaptic transmission suggesting that it may contribute to learning and memory. There is also evidence for an association between levels of alpha 7 nAChR and in sensorimotor gating impairments. To examine the role of alpha 7 nAChRs in learning and memory and sensorimotorgating, Acra7 homozygous mutant mice and their wild-type littermates were tested in a Pavlovian conditioned fear test, for spatial learningin the Morris water task, and in the prepulse inhibition paradigm. Exploratory activity, motor coordination, and startle habituation were also evaluated. Acra7 mutant mice displayed the same levels of contextual and auditory-cue condition fear as wild-type mice. Similarly, therewere no differences in spatial learning performance between mutant and wild-type mice. Finally, Acra7 mutant and wild-type mice displayed similar levels of prepulse inhibition. Other behavioral responses in Acra7 mutant mice were also normal, except for an anxiety-related behavior in the open-field test. The results of this study show that the absence of alpha 7 nAChRs has little impact on normal, base-line behavioral responses. Future studies will examine the contribution of alpha 7 nAChR to the enhancement of learning and sensorimotor gating followingnicotine treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:36:34