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Titolo:
LONG-TERM BUT NOT SHORT-TERM PLASTICITY AT MOSSY FIBER SYNAPSES IS IMPAIRED IN NEURAL CELL-ADHESION MOLECULE-DEFICIENT MICE
Autore:
CREMER H; CHAZAL G; CARLETON A; GORIDIS C; VINCENT JD; LLEDO PM;
Indirizzi:
INST ALFRED FESSARD,CNRS,AVE TERRASSE F-91198 GIF SUR YVETTE FRANCE INST ALFRED FESSARD,CNRS F-91198 GIF SUR YVETTE FRANCE UNIV MEDITERRANEE,INSERM,CNRS,INST DEV BIOL F-13288 MARSEILLE 9 FRANCE
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 95, anno: 1998,
pagine: 13242 - 13247
SICI:
0027-8424(1998)95:22<13242:LBNSPA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC PLASTICITY; FASCICLIN-II; FUNCTIONAL COMPONENTS; GENETIC DISSECTION; POTENTIATION; NCAM; HIPPOCAMPUS; TRANSMISSION; GROWTH; FASCICULATION;
Keywords:
CELL ADHESION MOLECULES; FREQUENCY FACILITATION; PAIRED-PULSE FACILITATION; LONG-TERM POTENTIATION; EXCITATORY SYNAPSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
H. Cremer et al., "LONG-TERM BUT NOT SHORT-TERM PLASTICITY AT MOSSY FIBER SYNAPSES IS IMPAIRED IN NEURAL CELL-ADHESION MOLECULE-DEFICIENT MICE", Proceedings of the National Academy of Sciences of the United Statesof America, 95(22), 1998, pp. 13242-13247

Abstract

Cell adhesion molecules (CAMs) are known to be involved in a variety of developmental processes that play key roles in the establishment ofsynaptic connectivity during embryonic development, but recent evidence implicates the same molecules in synaptic plasticity of the adult. In the present study, we have used neural CAM (NCAM)-deficient mice, which have learning and behavioral deficits, to evaluate NCAM function in the hippocampal mossy fiber system. Morphological studies demonstrated that fasciculation and laminar growth of mossy fibers were strongly affected, leading to innervation of CA3 pyramidal cells at ectopic sites, whereas individual mossy fiber boutons appeared normal. Electrophysiological recordings performed in hippocampal slice preparations revealed that both basal synaptic transmission and two forms of short-term plasticity, i,e,, paired-pulse facilitation and frequency facilitation, were normal in mice lacking all forms of NCAM, However, long-termpotentiation of glutamatergic excitatory synapses after brief trains of repetitive stimulation was abolished. Taken together, these resultsstrongly suggest that in the hippocampal mossy fiber system, NCAM is essential both for correct axonal growth and synaptogenesis and for long term changes in synaptic strength.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:56:19