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Titolo:
REGULATION OF MATRIX METALLOPROTEINASE-9 AND INHIBITION OF TUMOR INVASION BY THE MEMBRANE-ANCHORED GLYCOPROTEIN RECK
Autore:
TAKAHASHI C; SHENG ZQ; HORAN TP; KITAYAMA H; MAKI M; HITOMI K; KITAURA Y; TAKAI S; SASAHARA RM; HORIMOTO A; IKAWA Y; RATZKIN BJ; ARAKAWA T; NODA M;
Indirizzi:
KYOTO UNIV,GRAD SCH MED,DEPT MOL ONCOL,SAKYO KU,YOSHIDA KONOE CHO KYOTO 6068501 JAPAN KYOTO UNIV,GRAD SCH MED,DEPT MOL ONCOL,SAKYO KU KYOTO 6068501 JAPAN JAPANESE FDN CANC RES,INST CANC,DEPT VIRAL ONCOL,TOSHIMA KU TOKYO 1700012 JAPAN AMGEN INC,AMGEN CTR THOUSAND OAKS CA 91320 NAGOYA UNIV,GRAD SCH BIOAGR SCI,DEPT APPL MOL BIOSCI,CHIKUSA KU NAGOYA AICHI 4648601 JAPAN INT MED CTR JAPAN,CLIN RES INST,DEPT GENET,SHINJYUKU KU TOKYO 1620052JAPAN TOKYO MED & DENT UNIV,DEPT RETROVIRAL REGULAT,DIV MED RES,BUNKYO KU TOKYO 1130034 JAPAN
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 95, anno: 1998,
pagine: 13221 - 13226
SICI:
0027-8424(1998)95:22<13221:ROMMAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL INVASION; RAS ONCOGENE; GENE; TRANSFORMATION; EXPRESSION; SELECTION; SURFACE; CANCER; CDNA; LINE;
Keywords:
RAS SIGNALING; TRANSFORMATION; METASTASIS; PROTEASE INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
C. Takahashi et al., "REGULATION OF MATRIX METALLOPROTEINASE-9 AND INHIBITION OF TUMOR INVASION BY THE MEMBRANE-ANCHORED GLYCOPROTEIN RECK", Proceedings of the National Academy of Sciences of the United Statesof America, 95(22), 1998, pp. 13221-13226

Abstract

A human fibroblast cDNA expression library was screened for cDNA clones giving rise to flat colonies when transfected into v-Ki-ras-transformed NIH 3T3 cells. One such gene, RECK, encodes a membrane-anchored glycoprotein of about 110 kDa with multiple epidermal growth factor-like repeats and serine-protease inhibitor-like domains, While RECK mRNA is expressed in various human tissues and untransformed cells, it is undetectable in tumor-derived cell lines and oncogenically transformed cells. Restored expression of RECK in malignant cells resulted in suppression of invasive activity with concomitant decrease in the secretion of matrix metalloproteinase-9 (MMP-9), a key enzyme involved in tumor invasion and metastasis. Moreover, purified RECK protein was found to bind to, and inhibit the proteolytic activity of, MMP-9. Thus, RECK may link oncogenic signals to tumor invasion and metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:52:42