Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A NOVEL FAMILY OF ANCIENT VERTEBRATE ODORANT RECEPTORS
Autore:
BERGHARD A; DRYER L;
Indirizzi:
UNIV HOUSTON,DEPT BIOL & BIOCHEM,SR2 HOUSTON TX 77204 UNIV HOUSTON,DEPT BIOL & BIOCHEM HOUSTON TX 77204 UMEA UNIV,DEPT CELL & MOL BIOL S-90187 UMEA SWEDEN
Titolo Testata:
Journal of neurobiology
fascicolo: 3, volume: 37, anno: 1998,
pagine: 383 - 392
SICI:
0022-3034(1998)37:3<383:ANFOAV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC-RECEPTOR; SITE-DIRECTED MUTAGENESIS; PROTEIN-COUPLED RECEPTORS; MUSCARINIC ACETYLCHOLINE-RECEPTORS; 3RD INTRACELLULAR LOOP; OLFACTORY EPITHELIUM; PETROMYZON-MARINUS; SEA LAMPREY; VISUAL PIGMENTS; LIGAND-BINDING;
Keywords:
OLFACTION; G PROTEIN-COUPLED RECEPTOR; PHYLOGENY; CYCLOSTOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
A. Berghard e L. Dryer, "A NOVEL FAMILY OF ANCIENT VERTEBRATE ODORANT RECEPTORS", Journal of neurobiology, 37(3), 1998, pp. 383-392

Abstract

Vertebrate odorant receptor (OR) genes have been isolated and characterized in several taxa, including bony fish and mammals. However, the search for more ancient vertebrate OR genes has been unsuccessful to date, indicating that these ancient genes share little sequence identity with previously isolated ORs, The lamprey (Lampetra fluviatilis) olfactory epithelium does not appear to express any of the modern vertebrate ORs previously identified in bony fish and mammals. We have isolated and characterized an ancient family of vertebrate membrane receptors from the olfactory epithelium of the lamprey, Sequence analysis reveals similarities with other Class A (rhodopsin-like) G protein coupledreceptors such as serotonin, dopamine, and histamine receptors, but the expression patterns of members of the new family, as well as certain conserved motifs, strongly suggest that the sequences encode ORs, Sequence similarity within the lamprey OR family is low, and Southern blot analysis suggests reduced-sized subfamilies. This novel vertebrate OR gene family, the most ancient isolated to date, is proposed to be involved in the detection of water-borne molecules in jawless fishes, Lamprey OR genes therefore represent a new level of diversity within the vertebrate OR gene family, but also provide clues as to how vertebrate ORs might have emerged. (C) 1998 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:47:32