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Titolo:
A MULTILOCUS GENOTYPING ASSAY FOR CARDIOVASCULAR-DISEASE
Autore:
CHENG S; PALLAUD C; GROW MA; SCHARF SJ; ERLICH HA; KLITZ W; PULLINGER CR; MALLOY MJ; KANE JP; SIEST G; VISVIKIS S;
Indirizzi:
ROCHE MOL SYST INC,DEPT HUMAN GENET,1145 ATLANTIC AVE ALAMEDA CA 94501 CTR MED PREVENT NANCY FRANCE UNIV CALIF BERKELEY,SCH PUBL HLTH BERKELEY CA 94720 UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PEDIAT SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS SAN FRANCISCO CA 94143
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 8, volume: 36, anno: 1998,
pagine: 561 - 566
SICI:
1434-6621(1998)36:8<561:AMGAFC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; CORONARY-ARTERY DISEASE; LIPOPROTEIN-LIPASE GENE; FAMILIAL COMBINED HYPERLIPIDEMIA; BETA-SYNTHASE DEFICIENCY; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; TRANSFER PROTEIN GENE; COAGULATION-FACTOR-V; MYOCARDIAL-INFARCTION; RISK FACTOR;
Keywords:
CARDIOVASCULAR DISEASE; MULTILOCUS GENOTYPING; OLIGONUCLEOTIDE ARRAY; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Cheng et al., "A MULTILOCUS GENOTYPING ASSAY FOR CARDIOVASCULAR-DISEASE", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 36(8), 1998, pp. 561-566

Abstract

In our efforts to develop diagnostic tests for complex multifactorialdisorders, and to assist the research community in evaluating geneticmarkers for predisposition to cardiovascular disease, we have developed a prototype assay to genotype up to 35 variable sites among 15 genes. The candidate markers in this panel were selected from biological pathways likely to contribute to the development and progression of cardiovascular disease. Each sample is amplified in two multiplex polymerase chain reactions that are then hybridized to an array of immobilized oligonucleotide probes. The assay has been applied to a population-based cohort representing 238 families; allele frequencies observed among 455 unrelated parents from this cohort agree with available literature values. Data from a cohort of 142 lipid-clinic patients were used to explore locus associations with arterial occlusion, as measured by quantitative angiography. This prototype assay provides a research tool for studies to assess the association of multiple markers with disease, and for clinical studies to evaluate marker association with patient responsiveness to experimental therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:29:18