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Titolo:
TRANSIENT DEVELOPMENTAL EXPRESSION OF MONOAMINE TRANSPORTERS IN THE RODENT FOREBRAIN
Autore:
LEBRAND C; CASES O; WEHRLE R; BLAKELY RD; EDWARDS RH; GASPAR P;
Indirizzi:
HOP LA PITIE SALPETRIERE,INSERM U106 F-75651 PARIS 13 FRANCE HOP LA PITIE SALPETRIERE,INSERM U106 F-75651 PARIS 13 FRANCE VANDERBILT UNIV,SCH MED,DEPT PHARMACOL NASHVILLE TN 37232 VANDERBILT UNIV,SCH MED,CTR MOL NEUROSCI NASHVILLE TN 37232 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL,PHYSIOL GRAD PROGRAM NEUROSCI & CELL BIOL SAN FRANCISCO CA 94143
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 401, anno: 1998,
pagine: 506 - 524
SICI:
0021-9967(1998)401:4<506:TDEOMT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE SEROTONIN TRANSPORTER; TYROSINE-HYDROXYLASE; THALAMIC PROJECTIONS; RAT NEOCORTEX; IMMUNOREACTIVE NEURONS; POSTNATAL-DEVELOPMENT; SOMATOSENSORY CORTEX; GROWTH CONES; BRAIN; MOUSE;
Keywords:
SEROTONIN TRANSPORTER; NOREPINEPHRINE TRANSPORTER; VESICULAR MONOAMINE TRANSPORTER; THALAMUS; DEVELOPMENT; SENSORY PATHWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
C. Lebrand et al., "TRANSIENT DEVELOPMENTAL EXPRESSION OF MONOAMINE TRANSPORTERS IN THE RODENT FOREBRAIN", Journal of comparative neurology, 401(4), 1998, pp. 506-524

Abstract

Neurons in first-order sensory thalamic nuclei have been shown to express functional plasma membrane serotonin (SERT) and vesicular monoamine (VMAT2) transporters during early postnatal development. In the present study, Re provide an extensive description of the spatial and thetemporal patterns of VMAT2 and SEPT expression, during early embryonic development and postnatal life, by using in situ hybridization and immunocytochemistry. VMAT2 and SERT genes are transiently expressed in a wide population of non-monoaminergic neurons in the central and peripheral nervous system with a large overlap in the temporal and spatialpattern of expression of both genes. A selective pattern of expression of both genes was observed in the thalamus with expression limited to the dorsal thalamus and more particularly to primary sensory relay nuclei that convey point to point projection maps. Transient expressionof the transporters was also observed in sensory cranial nerves, in the hippocampus, cerebral cortex, septum, and amygdala. VMAT2 and SERT gene expression was not necessarily linked, as some neural populationsexpressed only VMAT2, while others only contained SERT. Since VMAT2 serves to transport catecholamines besides serotonin, we examined the developmental expression of the plasma membrane dopamine and norepinephrine transporters but found no transient expression of these genes. Despite minor temporal disparities, VMAT2 and SERT extinguished almost simultaneously during the second and third weeks of post-natal life. These expressions did not seem to be dependent on peripheral neural inputs, since monocular enucleations and infraorbital nerve cuts effected on the day of birth, did not modify the period of transporter expression or of extinction. a 1998 Wiley-Liss, Inc.

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Documento generato il 05/04/20 alle ore 06:54:24