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Titolo:
PERIAQUEDUCTAL GRAY-MATTER PROJECTION TO THE PARABRACHIAL NUCLEUS IN RAT
Autore:
KROUT KE; JANSEN ASP; LOEWY AD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROBIOL & ANAT,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROBIOL & ANAT ST LOUIS MO 63110
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 401, anno: 1998,
pagine: 437 - 454
SICI:
0021-9967(1998)401:4<437:PGPTTP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; FOS-LIKE IMMUNOREACTIVITY; EFFERENT PROJECTIONS; ELECTROPHYSIOLOGICAL EVIDENCE; PHA-L; TOPOGRAPHIC ORGANIZATION; DEFENSE REACTION; GLUTAMATE MICROSTIMULATION; CARDIOVASCULAR COMPONENTS; SUBNUCLEAR LOCALIZATION;
Keywords:
AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR REGULATION; FIGHT-OR-FLIGHT RESPONSE; NOCICEPTION; VISCERAL AFFERENT PATHWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Krout et al., "PERIAQUEDUCTAL GRAY-MATTER PROJECTION TO THE PARABRACHIAL NUCLEUS IN RAT", Journal of comparative neurology, 401(4), 1998, pp. 437-454

Abstract

The efferent projections from the periaqueductal gray matter (PAG) tothe parabrachial nucleus (PB) were studied in the rat following microinjections of the anterograde axonal tracer Phaseolus vulgaris-leucoagglutinin (PHA-L) into restricted regions of the PAG. The dorsomedial and dorsolateral PAG columns project almost exclusively to the superiorlateral PB subnucleus, whereas the lateral and ventrolateral PAG columns project to five lateral PB sites: dorsal lateral subnucleus, medial and lateral crescent areas (which flank the dorsal lateral PB subnucleus), central lateral subnucleus (rostral portion), and superior lateral subnucleus. The PAG region lying near the cerebral aqueduct projects to five lateral PB sites: external lateral subnucleus (inner subdivision), medial and lateral crescent areas, central lateral subnucleus (rostral portion), and dorsal lateral subnucleus. The internal lateralPB subnucleus, which projects exclusively to the intralaminar thalamic nuclei, and the Kolliker-Fuse nucleus were not innervated by the PAG. T he PAG selectively innervates individual PB subnuclei that may be part of the spino-parachio-forebrain pathway. All PAG columns, including the aqueductal region, project to the superior lateral PB subnucleus, a presumed nociceptive relay site that receives inputs from multiple spinal cord regions (laminae I, V, and VIII) and projects to the ventromedial and retrochiasmatic hypothalamic areas-two regions that havebeen implicated in complex goal-directed behavior (e.g., food intake and reproductive function). Earlier studies demonstrated that the dorsal lateral and external lateral PB subnuclei (inner division) receive overlapping inputs from the superficial dorsal horn (laminae I and II)and the nucleus tractus solitarius, and both PB subnuclei send projections to limbic forebrain areas (e.g., hypothalamus, preoptic region, amygdala). Because the PAG projects to both of these PB subnuclei, this projection system possibly functions as a behavioral state-dependentfilter system that modulates ascending nociceptive and/or visceral information as it is relayed through the PB to forebrain sites. (C) 1998Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:01:02