Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VIRAL CHARACTERISTICS OF HUMAN-PAPILLOMAVIRUS INFECTION AND ANTIOXIDANT LEVELS AS RISK-FACTORS FOR CERVICAL DYSPLASIA
Autore:
HO GYF; PALAN PR; BASU J; ROMNEY SL; KADISH AS; MIKHAIL M; WASSERTHEILSMOLLER S; RUNOWICZ C; BURK RD;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT GYNECOL & OBSTET BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT IMMUNOL & MICROBIOL BRONX NY 10461
Titolo Testata:
International journal of cancer
fascicolo: 5, volume: 78, anno: 1998,
pagine: 594 - 599
SICI:
0020-7136(1998)78:5<594:VCOHIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CAROTENE; INTRAEPITHELIAL NEOPLASIA; ASCORBIC-ACID; HEALTHY WOMEN; PLASMA; CANCER; RESPONSES; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G.Y.F. Ho et al., "VIRAL CHARACTERISTICS OF HUMAN-PAPILLOMAVIRUS INFECTION AND ANTIOXIDANT LEVELS AS RISK-FACTORS FOR CERVICAL DYSPLASIA", International journal of cancer, 78(5), 1998, pp. 594-599

Abstract

Genital human papillomavirus (HPV) infection is the major causal factor of cervical intraepithelial neoplasia (CIN); The potential role of nutrition as an additional, independent risk factor for CIN has: not been appropriately addressed in the context of HPV. This case-control study evaluated the etiologic role of HPV in terms of viral type and load and examined the association between CIN and plasma levels of micronutrients adjusting for HPV. Cases (n = 378) with histo-pathologicallyconfirmed CIN and controls (n = 366) with no history of abnormal Pap smears were recruited from colposcopy and gynecology clinics, respectively, Risk of CIN was significantly increased among women who were infected with multiple HPV types (odds ratio [OR]= 21.06), a high viral load (OR = 13.08) and HPV 16 (OR = 62.49). After adjusting for HPV positivity and demographic factors, there was an inverse correlation between plasma at-tocopherol and risk of CIN (OR = 0.15). Plasma ascorbic acid was protective at a high level of greater than or equal to 0.803 mg/dl (OR = 0.46). CIN was not associated with plasma retinol and p-carotene levels. The effect of genital HPV infection on CIN development is highly influenced by oncogenic viral type and high viral load. Vitamins C and E may play an independent protective role in development of CIN that needs to be confirmed in prospective studies. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:56:32