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Titolo:
MORPHOMETRIC EVALUATION OF PARANEOPLASTIC NEUROPATHIES ASSOCIATED WITH CARCINOMAS, LYMPHOMAS, AND DYSPROTEINEMIAS
Autore:
WANG JF; SCHRODER JM;
Indirizzi:
UNIV AACHEN KLINIKUM,RHEIN WESTFAL TH AACHEN,INST NEUROPATHOL,PAUWELSSTR 30 D-52057 AACHEN GERMANY RHEIN WESTFAL TH AACHEN,FAC MED,INST NEUROPATHOL AACHEN GERMANY
Titolo Testata:
Journal of the peripheral nervous system
fascicolo: 4, volume: 3, anno: 1998,
pagine: 259 - 266
SICI:
1085-9489(1998)3:4<259:MEOPNA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IGM MONOCLONAL GAMMOPATHY; PARA-NEOPLASTIC SYNDROMES; CELL LUNG-CANCER; SURAL NERVE; UNDETERMINED SIGNIFICANCE; PERIPHERAL NEUROPATHY; NEUROLOGIC DISORDERS; BODY DISEASE; ENCEPHALOMYELITIS; POLYNEUROPATHY;
Keywords:
PARANEOPLASTIC NEUROPATHY; LYMPHOMA; DYSPROTEINEMIA; MYELIN SHEATH; AXON; SURAL NERVE; MORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Wang e J.M. Schroder, "MORPHOMETRIC EVALUATION OF PARANEOPLASTIC NEUROPATHIES ASSOCIATED WITH CARCINOMAS, LYMPHOMAS, AND DYSPROTEINEMIAS", Journal of the peripheral nervous system, 3(4), 1998, pp. 259-266

Abstract

Paraneoplastic peripheral neuropathies are caused by indirect effectsof carcinomas, mainly small cell bronchogenic carcinomas, lymphoproliferative disorders (lymphomas: myelomas, polycythemia vera), and dysproteinemias (benign monoclonal paraproteinemia, Waldenstrom's macroglobulinemia) including cryoglobulinemias. Those associated with carcinomas are usually considered as severe, those associated with benign gammopathies (monoclonal gammopathies of unknown significance, MGUS) as mild, and those with cryoglobulinemias as of variable severity. In a larger series of 104 autopsy and biopsy cases, we noted a wide range of severity concerning various morphometric parameters of peripheral nerve fibers by evaluating sural nerves. There were no apparent morphometricdifferences between the groups of disorders. The most valuable parameter of optic-electronic evaluation and comparison turned out to be themyelin area expressed as a percentage of the endoneurial area becausethis measure comprises the relative number, size, and myelin thickness of the myelinated nerve fibers. In the 104 cases of the three disease groups, most of the cases (38 cases; 36.5%) showed a moderate reduction of the myelin sheath area per endoneurial area of sural nerves. This was followed by 34 cases (32.7%) with severe and very severe reduction. Twenty-nine cases (27.9%) presented with mild reduction. It is concluded that the severity of the neuropathy depends largely on the stage of the disease and the time of progression rather than on the type of the underlying disorder.

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Documento generato il 03/12/20 alle ore 20:59:35