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Titolo:
FIMBRIA-FORNIX CUT AFFECTS SPONTANEOUS ACTIVITY, 2-WAY AVOIDANCE AND DELAYED NON MATCHING-TO-SAMPLE, BUT NOT LATENT INHIBITION
Autore:
WEINER I; FELDON J; TARRASCH R; HAIRSTON I; JOEL D;
Indirizzi:
TEL AVIV UNIV,DEPT PSYCHOL IL-69978 TEL AVIV ISRAEL ETH ZURICH,INST TOXICOL,LAB BEHAV BIOL & FUNCT TOXICOL CH-8603 SCHWERZENBACH SWITZERLAND
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 96, anno: 1998,
pagine: 59 - 70
SICI:
0166-4328(1998)96:1-2<59:FCASA2>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; PRONE NORMAL SUBJECTS; HIPPOCAMPAL-LESIONS; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; CHRONIC AMPHETAMINE; ENTORHINAL CORTEX; WORKING-MEMORY; STIMULUS CONFIGURATION; ATTENTIONAL DEFICIT;
Keywords:
FIMBRIA-FORNIX; LATENT INHIBITION; ACTIVITY; 2-WAY ACTIVE AVOIDANCE; DELAYED-NON-MATCH-TO-SAMPLE; CONTEXT; LESION; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
128
Recensione:
Indirizzi per estratti:
Citazione:
I. Weiner et al., "FIMBRIA-FORNIX CUT AFFECTS SPONTANEOUS ACTIVITY, 2-WAY AVOIDANCE AND DELAYED NON MATCHING-TO-SAMPLE, BUT NOT LATENT INHIBITION", Behavioural brain research, 96(1-2), 1998, pp. 59-70

Abstract

Latent inhibition (LI) consists of a decrement in conditioning to a stimulus as a result of its prior nonreinforced preexposure. Based on evidence pointing to the involvement of the hippocampus and the nucleusaccumbens (NAC) in LI disruption, it has been proposed that LI depends on the integrity of the subicular input to the NAG. Since fibers originating in the subiculum and destined for the NAC run through the fimbria-fornix, we assessed the effects of fimbria-fornix lesion, made using a knife cut, on LI. In addition, we assessed the effects of the fimbria-fornix cut in three tests known to be sensitive to lesions to the hippocampal region, namely, spontaneous activity, two-way active avoidance and delayed-non-matching-to-sample. In accord with previously documented effects of lesions to the hippocampus and related structures, the fimbria-fornix cut increased spontaneous activity (Experiment 1), facilitated the acquisition of two-way active avoidance (Experiment 3), and produced a delay-dependent deficit in the delayed-non-match-to-sample task (Experiment 4), demonstrating that it disrupted hippocampal functioning. In contrast, LI remained unaffected by the fimbria-fornix cut (Experiment 2), indicating that disruption of subicular input to the NAC is not responsible for the attenuation of LI following non-selective hippocampal lesions. The implications of these results for the neural circuitry of LI are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:18:55