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Titolo:
THE ABSENCE OF EFFECT OF GLUCOSE ON MEMORY IS ASSOCIATED WITH LOW SUSCEPTIBILITY TO THE AMNESTIC EFFECTS OF SCOPOLAMINE IN A STRAIN OF MICE
Autore:
MESSIER C;
Indirizzi:
UNIV OTTAWA,SCH PSYCHOL,VANIER ROOM 215 OTTAWA ON K1N 6N5 CANADA
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 96, anno: 1998,
pagine: 47 - 57
SICI:
0166-4328(1998)96:1-2<47:TAOEOG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-GLUCOSE; AGED RATS; ACETYLCHOLINE-RELEASE; INVIVO MICRODIALYSIS; CHOLINERGIC ACTIVITY; MAZE PERFORMANCE; SENILE DEMENTIA; ALZHEIMER-TYPE; ENHANCEMENT; IMPROVEMENT;
Keywords:
AGING; GLUCOSE; HIPPOCAMPUS; INSULIN; MEMORY; MOUSE; SCOPOLAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
C. Messier, "THE ABSENCE OF EFFECT OF GLUCOSE ON MEMORY IS ASSOCIATED WITH LOW SUSCEPTIBILITY TO THE AMNESTIC EFFECTS OF SCOPOLAMINE IN A STRAIN OF MICE", Behavioural brain research, 96(1-2), 1998, pp. 47-57

Abstract

In this series of experiments, we examined the ability of post-training glucose injections to improve memory of the Balb/cAnNCrlBR strain of mice for a bar-pressing task. We could not replicate this effect which has been demonstrated in many other strains of mice including Balb/cbyJ, a related strain. We found that the Balb/cAnNCrlBR strain of mice is also much less sensitive to the disrupting effects produced by pre- or post-training injections of the competitive cholinergic antagonist scopolamine. This strain also shows altered glucoregulation compared to the Balb/cbyJ strain. The absence of glucose effects on memory inBalb/cAnNCrlBR mice appears to be associated with decreased sensitivity to cholinergic antagonists. These results can be contrasted with previous ones obtained in a related strain, the Balb/cbyJ, in which glucose was shown to improve memory while scopolamine could easily disruptmemory processes. Taken together, these data provide additional indirect support for the hypothesis that glucose improvement of memory is closely linked to a functional interaction with central cholinergic systems, The comparison of these two strains could be the basis for a useful animal model to investigate the relationship between age-related changes in memory and central cholinergic function. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:06:58