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Titolo:
THE DIAZOXIDE DERIVATIVE -3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-S,S-DIOXIDE AUGMENTS AMPA-MEDIATED AND GABA-MEDIATED SYNAPTIC RESPONSES IN CULTURED HIPPOCAMPAL-NEURONS
Autore:
YAMADA KA; HILL MW; HU YF; COVEY DF;
Indirizzi:
ST LOUIS CHILDRENS HOSP,CTR STUDY NERVOUS SYST INJURY ST LOUIS MO 63178 ST LOUIS CHILDRENS HOSP,DEPT NEUROL ST LOUIS MO 63178 ST LOUIS CHILDRENS HOSP,DEPT PEDIAT ST LOUIS MO 63110 ST LOUIS CHILDRENS HOSP,DEPT PEDIAT NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Neurobiology of disease
fascicolo: 3, volume: 5, anno: 1998,
pagine: 196 - 205
SICI:
0969-9961(1998)5:3<196:TDD->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RECEPTOR DESENSITIZATION; S,S-DIOXIDE IDRA-21; RAT HIPPOCAMPUS; TIME-COURSE; CYCLOTHIAZIDE; CURRENTS; MODULATOR; SLICES; MEMORY;
Keywords:
AMPA; CYCLOTHIAZIDE; AUTAPSE; EXCITATORY POSTSYNAPTIC CURRENT; BENZOTHIADIAZINE; THIAZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Yamada et al., "THE DIAZOXIDE DERIVATIVE -3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-S,S-DIOXIDE AUGMENTS AMPA-MEDIATED AND GABA-MEDIATED SYNAPTIC RESPONSES IN CULTURED HIPPOCAMPAL-NEURONS", Neurobiology of disease, 5(3), 1998, pp. 196-205

Abstract

The diazoxide derivative -3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide (IDRA21) enhances memory and learning in rodents, most likely by potentiating AMPAergic synaptic activity. We examined IDRA21's effect upon AMPAergic synaptic currents and whole-cell glutamate currents in cultured rat hippocampal neurons to determine whether IDRA21 was a partial modulator of AMPA receptor desensitization and deactivation. Comparable to cyclothiazide, IDRA21 prolonged AMPAergic autaptic currents (5.6 times control, EC50 150 mu M) and slowed the rate of AMPA deactivation (3 times control) following 1-ms applications of 1 mM glutamate to excised, outside-out membrane patches. IDRA21 also augmented autaptic GABA currents by 27 +/- 8.1%, although it had two opposing effects, reducing the peak amplitude versus prolonging autaptic GABA currents. IDRA21 (200 mu M) inhibited whole-cell GABA currents elicited by exogenously applied 1 mM GABA by 41 +/- 11%. At sufficient concentrations, IDRA21 reduced AMPA receptor desensitization and slowed the rate ofdeactivation, most consistent with full agonist activity with lower potency compared to cyclothiazide. IDRA21 slightly augments GABAergic synaptic currents. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:57:17