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Titolo:
HIPPOCAMPAL MODULATION OF CINGULO-THALAMIC NEURONAL-ACTIVITY AND DISCRIMINATIVE AVOIDANCE-LEARNING IN RABBITS
Autore:
KANG E; GABRIEL M;
Indirizzi:
UNIV ILLINOIS,BECKMAN INST,405 N MATHEWS AVE URBANA IL 61801 UNIV ILLINOIS,BECKMAN INST URBANA IL 61801 UNIV ILLINOIS,DEPT PSYCHOL URBANA IL 61801 STANFORD UNIV,DEPT PSYCHOL STANFORD CA 94305
Titolo Testata:
Hippocampus (New York, N.Y.)
fascicolo: 5, volume: 8, anno: 1998,
pagine: 491 - 510
SICI:
1050-9631(1998)8:5<491:HMOCNA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTORHINAL CORTEX; SUBICULAR COMPLEX; ANTERIOR THALAMUS; CORTICAL-LESIONS; LIMBIC THALAMUS; UNIT-ACTIVITY; RAT; CONNECTIONS; MEMORY; BEHAVIOR;
Keywords:
HIPPOCAMPUS; POSTERIOR CINGULATE CORTEX; SUBICULUM; ANTERIOR THALAMUS; MEDIAL DORSAL THALAMUS; MEMORY; LEARNING; NEURAL CIRCUITRY; MULTISITE RECORDING; ACTIVE AVOIDANCE CONDITIONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
E. Kang e M. Gabriel, "HIPPOCAMPAL MODULATION OF CINGULO-THALAMIC NEURONAL-ACTIVITY AND DISCRIMINATIVE AVOIDANCE-LEARNING IN RABBITS", Hippocampus (New York, N.Y.), 8(5), 1998, pp. 491-510

Abstract

Two experiments assessed the effects of 1) combined subicular complexand posterior cingulate cortical lesions on training-induced neuronalactivity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesionson TIA in cingulate cortex and in the AV and MD thalamic nuclei. The rabbits acquired a conditioned avoidance response (CR), stepping in anactivity wheel upon hearing a 0.5-s tone (CS+), in order to prevent afoot-shock scheduled 5 s after tone onset. No response was required after a different, safety-predictive tone (CS-). In experiment 1 the combined subicular and cingulate cortical lesions enhanced thalamic TIA during acquisition and increased CR incidence in the First session of acquisition. These results confirmed the hypothesis that subicular andcingulate cortical efferents are not essential for thalamic TIA or for avoidance learning. Hippocampal lesions (experiment 2) also enhancedthalamic TIA. However, unlike subicular lesions, hippocampal lesions enhanced posterior cingulate cortical TIA as well, especially during extinction training. Hippocampal lesions did not affect CR performance. The results suggested that subicular excitatory efferents are responsible for incrementing cingulate cortical TIA, which is viewed as subserving associative attention. Activity from hippocampus downregulates the cue-elicited neuronal activity of the cingulo-thalamic circuits by suppressing the excitatory influence of the subiculum. The hippocampalinfluence reduces cingulo-thalamic cue-elicited activation in particular circumstances, such as the onset of CR extinction, when an expected reinforcer is omitted. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 00:44:50