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Titolo:
NEURONAL INJURY INCREASES RETROGRADE AXONAL-TRANSPORT OF THE NEUROTROPHINS TO SPINAL SENSORY NEURONS AND MOTOR-NEURONS VIA MULTIPLE RECEPTOR MECHANISMS
Autore:
CURTIS R; TONRA JR; STARK JL; ADRYAN KM; PARK JS; CLIFFER KD; LINDSAY RM; DISTEFANO PS;
Indirizzi:
MILLENNIUM PHARMACEUT INC,640 MEM DR CAMBRIDGE MA 02139 REGENERON PHARMACEUT INC TARRYTOWN NY 10591
Titolo Testata:
Molecular and cellular neurosciences (Print)
fascicolo: 3, volume: 12, anno: 1998,
pagine: 105 - 118
SICI:
1044-7431(1998)12:3<105:NIIRAO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; DORSAL-ROOT GANGLION; PERIPHERAL-NERVE; SCIATIC-NERVE; MESSENGER-RNA; ADULT-RAT; HORSERADISH-PEROXIDASE; CELL-DEATH; IN-VIVO; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
R. Curtis et al., "NEURONAL INJURY INCREASES RETROGRADE AXONAL-TRANSPORT OF THE NEUROTROPHINS TO SPINAL SENSORY NEURONS AND MOTOR-NEURONS VIA MULTIPLE RECEPTOR MECHANISMS", Molecular and cellular neurosciences (Print), 12(3), 1998, pp. 105-118

Abstract

We investigated the retrograde axonal transport of I-125-labeled neurotrophins (NGF, BDNF, NT-3, and NT-4) from the sciatic nerve to dorsalroot ganglion (DRG) sensory neurons and spinal motor neurons in normal rats or after neuronal injury. DRG neurons showed increased transport of all neurotrophins following crush injury to the sciatic nerve. This was maximal 1 day after sciatic nerve crush and returned to controllevels after 7 days. I-125-BDNF transport from sciatic nerve was elevated with injection either proximal to the lesion or directly into thecrush site and after transection of the dorsal roots. All neurotrophin transport was receptor-mediated and consistent with neurotrophin binding to the low-affinity neurotrophin receptor (LNR) or Trk receptors. However, transport of I-125-labeled wheat germ agglutinin also increased 1 day after sciatic nerve crush, showing that increased uptake andtransport is a generalized response to injury in DRG sensory neurons. Spinal cord motor neurons also showed increased neurotrophin transport following sciatic nerve injury, although this was maximal after 3 days. The transport of I-125-NGF depended on the expression of LNR by injured motor neurons, as demonstrated by competition experiments with unlabeled neurotrophins. The absence of TrkA in normal motor neurons orafter axotomy was confirmed by immunostaining and in situ hybridization. Thus, increased transport of neurotrophic factors after neuronal injury is due to multiple receptor-mediated mechanisms including general increases in axonal transport capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:15:47