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Titolo:
CORRELATION BETWEEN CANNABINOID MEDIATED EFFECTS ON PAIRED-PULSE DEPRESSION AND INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE
Autore:
PATON GS; PERTWEE RG; DAVIES SN;
Indirizzi:
UNIV ABERDEEN,INST MED SCI,DEPT BIOMED SCI ABERDEEN AB25 2ZB SCOTLAND UNIV ABERDEEN,INST MED SCI,DEPT BIOMED SCI ABERDEEN AB25 2ZB SCOTLAND
Titolo Testata:
Neuropharmacology
fascicolo: 9, volume: 37, anno: 1998,
pagine: 1123 - 1130
SICI:
0028-3908(1998)37:9<1123:CBCMEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; ENANTIOMERIC CANNABINOIDS; NEUROTRANSMITTER UPTAKE; GABAERGIC TRANSMISSION; SELECTIVE ANTAGONIST; BRAIN SYNAPTOSOMES; INVERSE AGONIST; GLOBUS-PALLIDUS; MODULATION; CATALEPSY;
Keywords:
WIN55212-2; SR141716A; CANNABINOIDS; PAIRED PULSE DEPRESSION; GAMMA-AMINOBUTYRIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Paton et al., "CORRELATION BETWEEN CANNABINOID MEDIATED EFFECTS ON PAIRED-PULSE DEPRESSION AND INDUCTION OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE", Neuropharmacology, 37(9), 1998, pp. 1123-1130

Abstract

Cannabinoids cause an increase in synaptic transmission via gamma-aminobutyric acid (GABA) receptors and this may be the mechanism by whichactivation of CBI receptors blocks the induction of long-term potentiation (LTP). To test this hypothesis, we used paired pulse depression (PPD) of CA1 population spike responses recorded in the rat hippocampal slice as an index of GABA-ergic feedback inhibition, to establish whether the effects of a stereoselective CB1 receptor agonist on GABA-ergic transmission and LTP were correlated. The active isomer, WIN55212-2, blocked the induction of LTP and suppressed PPD over the concentration range-250 nM-5 mu M, whereas the inactive isomer, WIN55212-3, was inactive at 5 mu M. The effects of 5 mu M WIN55212-2 on both LTP and PPD were completely blocked by the CB1 receptor antagonist SR141716A (5mu M). The results show that the effects are correlated in that both suppression of PPD and blockade of induction of LTP are probably mediated by CB1 receptors. However, the suppression in PPD suggests that WIN55212-2 caused a decrease in GABA-ergic feedback transmission which would be expected to facilitate, rather than block, the induction of LTP. We therefore conclude that the blockade of LTP by cannabinoids is not via upregulation of GABA-ergic synaptic transmission. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:23:42